Clearance and removal of oxalate in children on intensified dialysis for primary hyperoxaluria type 1 F. Illies, K.-E. Bonzel, A.-M. Wingen, K. Latta,

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Presentation transcript:

Clearance and removal of oxalate in children on intensified dialysis for primary hyperoxaluria type 1 F. Illies, K.-E. Bonzel, A.-M. Wingen, K. Latta, P.F. Hoyer Kidney International Volume 70, Issue 9, Pages 1642-1648 (November 2006) DOI: 10.1038/sj.ki.5001806 Copyright © 2006 International Society of Nephrology Terms and Conditions

Figure 1 Influence of dialyzer (patient D). Blood flow rate was 150ml/min for each measurement. Plasma oxalate is given in proportion to initial plasma oxalate at each session of HD. Surface area and type of membrane of the different hemodialyzers are specified in the legend. Kidney International 2006 70, 1642-1648DOI: (10.1038/sj.ki.5001806) Copyright © 2006 International Society of Nephrology Terms and Conditions

Figure 2 Influence of blood flow rate (patient F). Each measurement was carried out with the hemodialyzer F30 by Fresenius (0.4m2, high flux). Plasma oxalate is given in proportion to initial plasma oxalate at each session of HD. Kidney International 2006 70, 1642-1648DOI: (10.1038/sj.ki.5001806) Copyright © 2006 International Society of Nephrology Terms and Conditions

Figure 3 Plasma oxalate, clearance of oxalate, and removal of oxalate in patient F. White columns represent urine, gray columns PD, and black columns HD. The period of collecting urine and dialysate started 8'o clock and ended the following morning. The HD session was interposed. There was one exception: the marked measurement (*) was carried out on a day immediately following a day with HD. The results of oxalate clearance and oxalate removal of HD of a single session were multiplied with the number of sessions per week and divided by seven. Measurements were carried out approximately every month. First, the patient was treated by urinary dilution and urinary crystal inhibition, then by PD, later HD was added. Complications of dialysis (catheter septicemia, peritonitis) arose as marked. Kidney International 2006 70, 1642-1648DOI: (10.1038/sj.ki.5001806) Copyright © 2006 International Society of Nephrology Terms and Conditions

Kidney International 2006 70, 1642-1648DOI: (10.1038/sj.ki.5001806) Copyright © 2006 International Society of Nephrology Terms and Conditions