Cell Injury Lab Dr Mamlook Elmagraby

Slides:

Advertisements

Similar presentations

Cell injury p.1 SYLLABUS:

Advertisements

CELL RESPONSE TO INJURY AND ADAPTIVE CELL REACTION

Cellular lesions I.

Necrosis Definition: Causes:. Development of Necrosis (2 mechanisms) irreversible damage to mitochondria (failure of ATP generation) ↓ anaerobic respiration.

Intracellular accumulations. Fatty change of the liver. In most cells, the well- preserved nucleus is squeezed into the displaced rim of cytoplasm about.

Intracellular Accumulations Fatty Change (Steatosis): Fatty Change (Steatosis): Abnormal accumulation of triglycerides within parenchymal cells seen in.

Cell injury is defined as A set of biochemical and morphological changes that occur when the state of homeostasis is disturbed by adverse influence.

Cell Injury, Cell Death, and Adaptations

Detection of Cellular Changes After Injury By: Light microscopy or gross examination  detect changes hours to days after injury Histochemical or ultrastructural.

Inflammation. Acute inflammation The cardinal signs of inflammation are rubor (redness), calor (heat), tumor (swelling), dolor (pain), and loss of function.

INFLAMMATION Acute And Chronic. The cardinal signs of inflammation.

Cell injury By Dr. Abdelaty Shawky Dr. Gehan Mohamed.

Cellular Responses To Stress

Necrosis and apoptosis

Liver and pancreas SYLLABUS: RBP(Robbins Basic Pathology) Chapters: The Liver and the Biliary Tract The Pancreas.

ปฏิบัติการ วิชา พยาธิ วิทยา ครั้งที่ 1 ภาควิชาพยาธิวิทยาและ นิติเวชศาสตร์ คณะแพทยศาสตร์ มหาวิทยาลัยนเรศวร.

Lecture on pathological anatomy for the 3-rd year students T.Filonenko

Respiratory system SYLLABUS: RBP(Robbins Basic Pathology) Chapters: The Lung and the Upper Respiratory Tract.

Irreversible cell injury Dr Heyam Awad FRCPath. Irreversible injury Necrosis Apoptosis.

Tongue: Herpes Simplex Glossitis Lab 8, Case 1. Cross section of the tongue There is an area along the surface of the tongue where the normal epithelium.

Hepatobiliary system Integrated practical

Pathology 11/25/20151 SECTION 2 CELL INJURY. Pathology 11/25/20152  Reversible  Irreversible Cellular Swelling Fatty Change Hyaline Change Amyloid Change.

ACUTE and CHRONIC INFLAMMATION. Vascular congestion.

Reversible cell injury  cellular swelling (Hydropic changes)  Fatty changes Irreversible cell injury  Necrosis  Apoptosis Cell Injury.

Cell Death: Necrosis Charles L. Hitchcock, MD, PhD Department of Pathology Wexner Medical Center at The Ohio State University.

Cell Injury. Slide 11: Vacuolar Degeneration Kidney Renal tubules –Note tiny small vacuoles –Displaced nucleus to the side Glomerulus.

Inflammation 5 Dr Heyam Awad FRCPath. topics to be covered in this lecture Outcome of acute inflammation. Morphology of acute inflammation. Chronic inflammation.

Cellular injury & adaptation.

Integrated practical Dr Shaesta Naseem

Inflammation p.2 SYLLABUS: RBP(Robbins Basic Pathology) Chapter: Acute and Chronic Inflammation PBD (Pathologic Basis of Disease) Infectious Diseases.

Cell injury By Dr. Abdelaty Shawky Dr. Gehan Mohamed.

Cell Injury, Cell Death, and Adaptations. Cell adaptation Hypertrophy Hyperplasia Atrophy Metaplasia.

Cell injury and inflammation Dr. Shaesta Naseem Foundation block-Pathology Practical.

Practical of Cell Injury Third Year 5th October 2015

Hepatitis. Hepatitis * Definition: Hepatitis is necro-inflammatory liver disease characterized by the presence of inflammatory cells in in the portal.

Tutorial prepaewd by Dr.Sadaf Konain Ansari for 2 nd year BDS IMDC Patho-dept. General Pathology  Necrosis Dr.Sadaf Konain Ansari.

CHRONIC SPECIFIC INFLAMMATION

Cellular Response Adaptive Disturbances of growth Inflammation and repair Immune response Non Adaptive Degeneration Neoplasia Dysplasia Necrosis.

Acute viral hepatitis There is disruption of lobular architecture, inflammatory cells in the portal tracts & sinusoids, and hepatocellular apoptosis (arrow).

Practical 1 Fatty change 28/2/2016. Contents Slide: Fatty change- liver Jar: Fatty liver Case 1 discussion.

Practical Pathology.

NECROSIS -Dr Sowmya Srinivas. DEFINITION NECROSIS Its an irriversible injury produced by enzymatic digestion of dead cellular elements APOPTOSIS.

Inflammation and repair

Patterns of Hepatic Injury

Necrosis is death of cells and tissues in the living animal.

2- Cell Death Apoptosis Necrosis.

Organ:Kidney Lesion:showing coagulative necrosis represented by pyknosis, karyolysis and karyorrhexis. Dignosis: Coagulative necrosis.

Cell injury, adaptation and death

NECROSIS “Necrosis is the morphological changes that follow cell death in a living tissue or organ, Resulting from the progressive degenerative action.

Organ: Kidney Lesion:Gross picture of kidney suffering from cloudy swelling showing pale color, round border and enlarged Diagnosis:cloudy swelling.

Digestive pathology 2.

Cellular responses to stress (Adaptations, injury and death) (2 of 5)

Death and Necrosis LECTURE FIVE DR.ABDIAZIZ ABDI MOHAMED ABDI

Tuberculous Lymphadenitis (15)

Cell Injury I – Cell Injury and Cell Death

The cardinal signs of inflammation are rubor (redness), calor (heat), tumor (swelling), dolor (pain), and loss of function. Seen here is skin with erythema,

Cell Injury, Cell Death, and Adaptations

Overview of Cell Injury and Cell Death

Morphological patterns of cell injury

Here is chronic endometritis with lymphocytes and plasma cells in the endometrial stroma. In general, the inflammatory infiltrate of chronic inflammation.

General Pathology (PATH 303) Lecture # 7

CELL INJURY for Medical (lecture 2)

FREE RADICAL INJURY, TYPES OF NECROSIS AND APOPTOSIS

Acute Inflammation.

Presentation transcript:

Cell Injury Lab Dr Mamlook Elmagraby اسم ورقم المقرر – Course Name and No. 5/28/2019

Lung, lung abscess (Liquefactive necrosis ) Several abscesses with irregular, rough-surfaced walls are seen. The purulent exudate in these abscesses has drained following sectioning to reveal the abscess cavities اسم ورقم المقرر – Course Name and No. 5/28/2019

Lung, pulmonary tuberculosis A tuberculous lung with a large area of caseous necrosis. The caseous debris is yellow-white and cheesy اسم ورقم المقرر – Course Name and No. 5/28/2019

Omentum, fat necrosis in a case of pancreatitis The white areas in the omentum represent calcium combined with free fatty acids اسم ورقم المقرر – Course Name and No. 5/28/2019

Liver, fatty change Identify the portal tract, the surrounding hepatocytes contain large, clear vacuoles filled with accumulated fat اسم ورقم المقرر – Course Name and No. 5/28/2019

Myocardial Infarct In the area of coagulative necrosis, there are homogeneous pink cytoplasm and loss of myocardial cell nuclei. The cellular architecture is preserved. اسم ورقم المقرر – Course Name and No. 5/28/2019

Liver, acute viral hepatitis Apoptotic hepatocyte appear as small cells with eosinophilic cytoplasm and a dark, degenerative nucleus. Sinusoidal inflammation is also present. اسم ورقم المقرر – Course Name and No. 5/28/2019