Asparagine and Glutamine: Co-conspirators Fueling Metastasis Ming Luo, Michael Brooks, Max S. Wicha  Cell Metabolism  Volume 27, Issue 5, Pages 947-949 (May 2018) DOI: 10.1016/j.cmet.2018.04.012 Copyright © 2018 Terms and Conditions

Figure 1 Multifaceted Roles of Asparagine and Glutamine in the Metastatic Cascade (A) In the breast, high levels of asparagine promote EMT, driving tumor cell migration, invasion, and intravasation. (B) In the circulation, exogenous asparagine promotes the survival of EMT-like tumor cells from shear and oxidant-induced stress. (C) At metastatic sites, increased asparagine bioavailability induces GLUL, driving glutamine biosynthesis and facilitating the accumulation of HIF1α and MYC, which in turn facilitates the transition of quiescent EMT-like tumor cells into a proliferative MET-like state, completing metastatic colonization. Cell Metabolism 2018 27, 947-949DOI: (10.1016/j.cmet.2018.04.012) Copyright © 2018 Terms and Conditions