Systemic lidocaine fails to improve postoperative morphine consumption, postoperative recovery and quality of life in patients undergoing posterior spinal.

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Presentation transcript:

Systemic lidocaine fails to improve postoperative morphine consumption, postoperative recovery and quality of life in patients undergoing posterior spinal arthrodesis. A double- blind, randomized, placebo-controlled trial G. Dewinter, P. Moens, S. Fieuws, B. Vanaudenaerde, M. Van de Velde, S. Rex British Journal of Anaesthesia Volume 118, Issue 4, Pages 576-585 (April 2017) DOI: 10.1093/bja/aex038 Copyright © 2017 The Author(s) Terms and Conditions

Fig 1 Flowchart. British Journal of Anaesthesia 2017 118, 576-585DOI: (10.1093/bja/aex038) Copyright © 2017 The Author(s) Terms and Conditions

Fig 2 Cumulative morphine requirements (milligrams) in the first 24 postoperative h for the lidocaine and the placebo group. Data are shown as individual values and as mean (sd). There was no significant difference between the lidocaine group (closed circles, n = 35) and the placebo group (closed squares, n = 35) (P = 0.22). British Journal of Anaesthesia 2017 118, 576-585DOI: (10.1093/bja/aex038) Copyright © 2017 The Author(s) Terms and Conditions

Fig 3 Pain scores (as assessed with the numeric rating scale (NRS) for pain) in both groups during the first three postoperative days. No significant difference was found for the mean NRS between the two groups (main effect time: P < 0.0001; main effect group: P = 0.71; interaction effect: P = 0.59). m = min, h = h after arrival at the postanesthesia care unit, d = day. British Journal of Anaesthesia 2017 118, 576-585DOI: (10.1093/bja/aex038) Copyright © 2017 The Author(s) Terms and Conditions

Fig 4 Kaplan-Meier survival plot showing the time until first defecation (A) and hospital stay (B). No significant difference was found for the time until first defecation and hospital stay between the lidocaine - and placebo group. British Journal of Anaesthesia 2017 118, 576-585DOI: (10.1093/bja/aex038) Copyright © 2017 The Author(s) Terms and Conditions