Volume 79, Issue 1, Pages (January 2011)

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Volume 79, Issue 1, Pages 128-134 (January 2011) Angiogenic growth factors correlate with disease severity in young patients with autosomal dominant polycystic kidney disease Berenice Y. Reed, Amirali Masoumi, Elwaleed Elhassan, Kim McFann, Melissa A. Cadnapaphornchai, David M. Maahs, Janet K. Snell- Bergeon, Robert W. Schrier Kidney International Volume 79, Issue 1, Pages 128-134 (January 2011) DOI: 10.1038/ki.2010.355 Copyright © 2011 International Society of Nephrology Terms and Conditions

Figure 1 Scatter plot of serum log10 vascular endothelial growth factor (VEGF) and log10 total renal volume. The plot depicts the uncorrected relationship between renal volume and serum VEGF. VEGF pg/ml and renal volume mm3. Kidney International 2011 79, 128-134DOI: (10.1038/ki.2010.355) Copyright © 2011 International Society of Nephrology Terms and Conditions

Figure 2 Total renal volume expressed by quartile of serum vascular endothelial growth factor (VEGF) level. Renal volume was adjusted for age, sex, and body surface area. VEGF range <50th percentile <440pg/ml; 50–75th percentile 224–2750pg/ml; >75th percentile 2950–18,000pg/ml. All P-values were corrected for multiple comparisons by the Tukey–Kramer correction.21 Kidney International 2011 79, 128-134DOI: (10.1038/ki.2010.355) Copyright © 2011 International Society of Nephrology Terms and Conditions

Figure 3 Total cyst volume expressed by quartile of serum vascular endothelial growth factor (VEGF) level. Cyst volume was adjusted for age and sex. VEGF range/quartile as presented in legend for Figure 2. All P-values were corrected for multiple comparisons by the Tukey–Kramer correction.21 Kidney International 2011 79, 128-134DOI: (10.1038/ki.2010.355) Copyright © 2011 International Society of Nephrology Terms and Conditions

Figure 4 Scatter plot of serum angiopoietin (Ang)-1 and log10 urinary protein excretion. The plot depicts the uncorrected relationship between 24h urinary protein excretion and serum Ang-1 level. Ang-1 ng/ml and urinary protein g/24h. Kidney International 2011 79, 128-134DOI: (10.1038/ki.2010.355) Copyright © 2011 International Society of Nephrology Terms and Conditions

Figure 5 Creatinine clearance expressed by quartile of serum vascular endothelial growth factor (VEGF) level. Creatinine clearance was corrected for height and weight and VEGF range/quartile is presented in legend for Figure 1. All P-values were corrected for multiple comparisons by the Tukey–Kramer correction.21 Kidney International 2011 79, 128-134DOI: (10.1038/ki.2010.355) Copyright © 2011 International Society of Nephrology Terms and Conditions

Figure 6 Scatter plot of serum log10 vascular endothelial growth factor (VEGF) and log10 left ventricular mass index (LVMI). The plot depicts the relationship between serum VEGF and LVMI. VEGF pg/ml and LVMI g/m2. Kidney International 2011 79, 128-134DOI: (10.1038/ki.2010.355) Copyright © 2011 International Society of Nephrology Terms and Conditions

Figure 7 Left ventricular mass index (LVMI) expressed by quartile of serum vascular endothelial growth factor (VEGF) level. LVMI is already adjusted for body surface area, but age and sex were included as covariates. VEGF range/quartile as presented in legend for Figure 1. All P-values were corrected for multiple comparisons by the Tukey–Kramer correction.21 Kidney International 2011 79, 128-134DOI: (10.1038/ki.2010.355) Copyright © 2011 International Society of Nephrology Terms and Conditions