Yoav Gilad, Carlos D. Bustamante, Doron Lancet, Svante Pääbo

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Presentation transcript:

Natural Selection on the Olfactory Receptor Gene Family in Humans and Chimpanzees Yoav Gilad, Carlos D. Bustamante, Doron Lancet, Svante Pääbo The American Journal of Human Genetics Volume 73, Issue 3, Pages 489-501 (September 2003) DOI: 10.1086/378132 Copyright © 2003 The American Society of Human Genetics Terms and Conditions

Figure 1 Ka/Ks values for OR genes and pseudogenes in human and chimpanzee. Values for polymorphic and fixed sites are plotted as unblackened and blackened bars, respectively. The American Journal of Human Genetics 2003 73, 489-501DOI: (10.1086/378132) Copyright © 2003 The American Society of Human Genetics Terms and Conditions

Figure 2 Marginal posterior distribution of the directional selection parameter (γ=2Nes) on amino acid replacement mutations. A, Chimpanzee intact OR genes and pseudogenes. B, Human intact OR genes and pseudogenes. The American Journal of Human Genetics 2003 73, 489-501DOI: (10.1086/378132) Copyright © 2003 The American Society of Human Genetics Terms and Conditions

Figure 3 The joint distribution of γ and logω, as estimated from the MCMC scheme. A, Chimpanzee OR pseudogenes. B, Chimpanzee intact OR genes. C, Human OR pseudogenes. D, Human intact OR genes. The American Journal of Human Genetics 2003 73, 489-501DOI: (10.1086/378132) Copyright © 2003 The American Society of Human Genetics Terms and Conditions

Figure 4 Joint distribution of the scaled selection coefficient (2Ns) that is associated with mutations in OR genes and species divergence parameters (in units of τ). The American Journal of Human Genetics 2003 73, 489-501DOI: (10.1086/378132) Copyright © 2003 The American Society of Human Genetics Terms and Conditions

Figure 5 Three OR genes studied on human chromosome 11. Rectangles represent the OR coding regions along the chromosome. Indicated are P value of the H test, P(H); Tajima’s D value; and nucleotide diversity, π. The American Journal of Human Genetics 2003 73, 489-501DOI: (10.1086/378132) Copyright © 2003 The American Society of Human Genetics Terms and Conditions