Pregnancies in patients with congenital adrenal hyperplasia with complete or almost complete impairment of 21-hydroxylase activity  Wolfgang Hoepffner, M.D., Egbert Schulze, Ph.D., Joachim Bennek, Ph.D., Eberhard Keller, Ph.D., Helmut Willgerodt, Ph.D.  Fertility and Sterility  Volume 81, Issue 5, Pages 1314-1321 (May 2004) DOI: 10.1016/j.fertnstert.2003.10.024

FIGURE 1 Menstrual cycles and basal body temperature in response to modification of the therapy regimen up to the onset of pregnancy in our first CAH patient (patient 1 in Table 1). Hoepffner. Pregnancies in 21-hydroxylase deficiency. Fertil Steril 2004. Fertility and Sterility 2004 81, 1314-1321DOI: (10.1016/j.fertnstert.2003.10.024)

FIGURE 2 Salivary concentrations of 17-OHP in the morning in patient 1 (see Table 1 and Fig. 1) with two different therapy regimens. The values were much higher under therapy with hydrocortisone alone (filled squares) than under combination with fludrocortisone (filled circles). The thin lines depict salivary 17-OHP concentrations in two controls with ovulatory cycles. The conversion factor from SI units to conventional units (ng/mL) is 0.03305. Hoepffner. Pregnancies in 21-hydroxylase deficiency. Fertil Steril 2004. Fertility and Sterility 2004 81, 1314-1321DOI: (10.1016/j.fertnstert.2003.10.024)

FIGURE 3 Salivary concentrations of P in the morning in patient 1 under two different therapy regimens (see Fig. 2). The thin lines depict the lower and upper salivary P concentrations in ovulatory cycles from a normal population (data from Riad-Fahmy et al. [28]). The conversion factor from SI units to conventional units (ng/mL) is 0.00314. Hoepffner. Pregnancies in 21-hydroxylase deficiency. Fertil Steril 2004. Fertility and Sterility 2004 81, 1314-1321DOI: (10.1016/j.fertnstert.2003.10.024)

FIGURE 4 Menstrual cycle and basal body temperature in a CAH patient (patient 2 in Table 1) with optimal replacement therapy (see also Table 1). The pregnancy began within 3 months of the commencement of regular biphasic menstrual cycles. (A) The first cycle (June/July 1995). (B) The second cycle (July/August 1995). (C) The third cycle (August/September 1995). Hoepffner. Pregnancies in 21-hydroxylase deficiency. Fertil Steril 2004. Fertility and Sterility 2004 81, 1314-1321DOI: (10.1016/j.fertnstert.2003.10.024)