Santhi Voora, Deborah B. Adey American Journal of Kidney Diseases

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Management of Kidney Transplant Recipients by General Nephrologists: Core Curriculum 2019 Santhi Voora, Deborah B. Adey American Journal of Kidney Diseases DOI: 10.1053/j.ajkd.2019.01.031 Copyright © 2019 National Kidney Foundation, Inc. Terms and Conditions

Figure 1 Mechanisms of immunosuppression. Abbreviations: AP-1, activator protein 1; CTLA, cytotoxic T-lymphocyte–associated antigen; FTY, finglolimod; IKK, I κ B kinase; JAK3, Janus kinase 3; MAP, mitogen-activated protein; MHC, major histocompatibility complex; MPA, mycophenolic acid; NFAT, nuclear factor of activated T cells; NF-κB, nuclear factor κB; PI-3K, phosphoinositide 3-kinase; S-1-P, sphingosine-1-phosphate; TCR, T-cell receptor. Adapted from Halloran (N Engl J Med. 2004;351(26):2715-2729) with permission of the Massachusetts Medical Society; original content © 2004 Massachusetts Medical Society. American Journal of Kidney Diseases DOI: (10.1053/j.ajkd.2019.01.031) Copyright © 2019 National Kidney Foundation, Inc. Terms and Conditions