Tuure Kinnunen, MD, Kalle Jutila, BM, William W

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Presentation transcript:

Potential of an altered peptide ligand of lipocalin allergen Bos d 2 for peptide immunotherapy Tuure Kinnunen, MD, Kalle Jutila, BM, William W. Kwok, PhD, Marja Rytkönen-Nissinen, PhD, Anu Immonen, MSc, Soili Saarelainen, MSc, Ale Närvänen, PhD, Antti Taivainen, MD, PhD, Tuomas Virtanen, MD, PhD Journal of Allergy and Clinical Immunology Volume 119, Issue 4, Pages 965-972 (April 2007) DOI: 10.1016/j.jaci.2007.01.011 Copyright © 2007 American Academy of Allergy, Asthma & Immunology Terms and Conditions

Fig 1 Detection of peptide-specific T cells with MHC class II tetramers and CFSE dye dilution. Tetramer staining was performed on day 8 (A) and on day 15 (B) after stimulation with peptide-pulsed DCs. Representative results are shown for subject A-3. The percentages of divided tetramer-positive cells are indicated. The DR0401/HA306-318 tetramer was used as a control for staining. Journal of Allergy and Clinical Immunology 2007 119, 965-972DOI: (10.1016/j.jaci.2007.01.011) Copyright © 2007 American Academy of Allergy, Asthma & Immunology Terms and Conditions

Fig 2 Proliferative and cytokine responses of p127-142–induced and pN135D-induced long-term TCLs. A, The proliferative responses of the TCLs are expressed as Δcpm (mean of stimulated wells − mean of unstimulated wells). The amounts of IFN-γ (B), IL-4 (C), and IL-10 (D) produced were detected in the supernatants. The peptide concentration used for stimulation was 50 μmol/L. Journal of Allergy and Clinical Immunology 2007 119, 965-972DOI: (10.1016/j.jaci.2007.01.011) Copyright © 2007 American Academy of Allergy, Asthma & Immunology Terms and Conditions

Fig 3 Different patterns of T-cell cross-reactivity: the homologous peptide is not recognized (A); the homologous peptide is recognized with a similar avidity (B) or with higher avidity than the peptide used for induction (C). All 3 TCLs were obtained from subject A-5 on stimulation with the peptide analog pN135D. Journal of Allergy and Clinical Immunology 2007 119, 965-972DOI: (10.1016/j.jaci.2007.01.011) Copyright © 2007 American Academy of Allergy, Asthma & Immunology Terms and Conditions