Cec6- TRAINING ON BUILDING QUANTITATIVE AOP EUROTOX, Brussels, 2 Sept. 2018

PROGRAMME FOR THE TRAINING US EPA ORD-Duluth US Rep to OECD AOP Development Programme Topic Timing Speaker 1 Introduction and best practices in building AOPs 15 minutes + Q/A (5 min) Dan Villeneuve 2 Running Effectopedia for the first time 20 minutes + Q/A (10 min) Magda Sachana 3 Searching and exploring Effectopedia content   10 minutes + Q/A (5 min) 4 Creating an AOP in Effectopedia   BREAK 15 minutes 5 Add quantitative information to a key event and derive key event relationship within an AOP 20 minutes + Q/A (5 min) Hristo Aladjov 6 Transforming test data (in-vitro to in-vivo) 7 Using in-silico models (R or MATLAB) OECD Secretariat Paris Administrator AOP Development Programme IT Developer and consultant Bulgaria Developer of Effectopedia

… FEW WORDS OF INTRODUCTION TO AOP DEVELOPMENT PROGRAMME AOP concept (Ankley et al, 2010, etc…) Structured Programme for AOP development launched at OECD, 2012 IT Tools and Guidance for use aopkb.oecd.org aopwiki.org effectopedia.org learning.aopkb.org Expectations for applications to: chemicals evaluations and profilers, in vitro methods identification,… International Collaborative Open Review process AOP Publication (doi) Publicly accessible Modules Handbook for AOP developers Training material ad video tutorial