A B C D Supplementary Figure S1 UMSCC1 Plateau: 24 hr Pre-Treatment

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A B C D Supplementary Figure S1 UMSCC1 Plateau: 24 hr Pre-Treatment 24 hr Post-Treatment Supplementary Figure S1. Survival of UMSCC1 cells as a function of treatment time with PF-05212384 (10µM) treatment alone, a function of time with PF-05212384 (10µM) treatment followed by irradiation (8 Gy), or a function of time with DMSO control (10µM) treatment followed by irradiation (8 Gy) (A). Survival as a function of PF-05212384 (10µM) treatment time following irradiation (8 Gy) data not shown. Radiation survival curves for UMSCC1 plateau phase cells treated with PF-05212384 (10µM, Dashed Curve) or with DMSO Control (10µM, Solid Curve) for 24 hours prior to irradiation (Pre-Treatment), (B), or 24 hours following irradiation (Post-Treatment) (C). Column chart demonstrating a single representative experiment of exponentially growing FaDu cells treated with PF-05212384 (1µM) or with DMSO Control (1µM) for 24 hours prior to irradiation (Pre-Treatment) or 24 hours following irradiation (Post-Treatment) (D). Individual survival curves representative of n = 2-3 independent experiments fitted using the linear quadratic model. Dose modifying factors (DMFs) and drug treatment toxicities are shown in Table 1. D FaDu Exponential Growth: 24 hr 1µM PF-05212384 Treatment Post-IR Treatment Pre-IR Treatment