Christine S. Rinder, MD, Michael J. Smith, PhD, Henry M

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Presentation transcript:

Leukocyte Effects of C5a-Receptor Blockade During Simulated Extracorporeal Circulation Christine S. Rinder, MD, Michael J. Smith, PhD, Henry M. Rinder, MD, Daniel N. Cortright, PhD, Robbin M. Brodbeck, PhD, James E. Krause, PhD, Brian R. Smith, MD The Annals of Thoracic Surgery Volume 83, Issue 1, Pages 146-152 (January 2007) DOI: 10.1016/j.athoracsur.2006.08.019 Copyright © 2007 The Society of Thoracic Surgeons Terms and Conditions

Fig 1 Leukocyte CD11b upregulation during simulated extracorporeal circulation. CD11b expression was measured on neutrophils (PMN) at the time points shown (expressed as a percentage of baseline). The mean ± standard error of the mean from five experiments performed after addition of the C5aR antagonist (♦) and four control experiments using diluent (▴) are shown. The C5aR antagonist significantly inhibited neutrophil CD11b upregulation (p = 0.003). The Annals of Thoracic Surgery 2007 83, 146-152DOI: (10.1016/j.athoracsur.2006.08.019) Copyright © 2007 The Society of Thoracic Surgeons Terms and Conditions

Fig 2 Leukocyte–platelet conjugates during simulated extracorporeal circulation. The percentage of neutrophil (PMN)–platelet (A) and monocyte–platelet (B) conjugates is expressed as a percentage of baseline. The mean ± standard error of the mean from five experiments performed after addition of the C5aR antagonist (♦) and four control experiments using diluent (▴) are shown. The C5aR antagonist significantly inhibited both neutrophil–platelet (A) and monocyte–platelet conjugate formation (B; p < 0.001 for both). The Annals of Thoracic Surgery 2007 83, 146-152DOI: (10.1016/j.athoracsur.2006.08.019) Copyright © 2007 The Society of Thoracic Surgeons Terms and Conditions