A, analysis of cytoplasmic histone-associated DNA fragmentation in LNCaP cells following 24-h cotreatment with the indicated concentrations of SFN and.

Slides:

Advertisements

Similar presentations

Figure 6. Effect of Withaferin A (WA) treatment on leptin-induced signaling in breast cancer cells. A) Immunoblotting for pSTAT3 (Tyr705), total STAT3,

Advertisements

Expression of LKB1 tumor suppressor in non–small cell lung cancer determines sensitivity to 2-deoxyglucose Landon J. Inge, PhD, Keith D. Coon, PhD, Michael.

KG-501 suppresses NSCLC/IL-1β CM–induced migration of HUVECs by regulating IL-1β–induced CXC chemokine gene expression in NSCLC cells. KG-501 suppresses.

IL-1β significantly augments the angiogenic activity of NSCLC by inducing the expression of angiogenic CXC chemokine genes. IL-1β significantly augments.

IFN-γ Primes Keratinocytes for HSV-1–Induced Inflammasome Activation

IL-1β differentially regulates CXCL5 and CXCL8 protein secretion in NHTBE and NSCLC cells. IL-1β differentially regulates CXCL5 and CXCL8 protein secretion.

IL-1β stimulates CXCL5 and CXCL8 gene expression and protein secretion in A549 cells in a time- and dose-dependent manner. IL-1β stimulates CXCL5 and CXCL8.

Volume 26, Issue 2, Pages (August 2014)

STAT1 is phosphorylated and downregulated by the oncogenic tyrosine kinase NPM-ALK in ALK-positive anaplastic large-cell lymphoma by Chengsheng Wu, Ommoleila.

CDK4 is required for the hormone-independent growth of ER+ breast cancer cells. CDK4 is required for the hormone-independent growth of ER+ breast cancer.

Xiang Li, Feng Xu, Ekapun Karoopongse, A

Yongping Shao, Kaitlyn Le, Hanyin Cheng, Andrew E. Aplin

Lipopolysaccharide Activates Caspase-1 (Interleukin-1–Converting Enzyme) in Cultured Monocytic and Endothelial Cells by Ralf R. Schumann, Claus Belka,

MET Tyrosine Kinase Inhibitor Crizotinib (PF ) Shows Differential Antitumor Effects in Non-small Cell Lung Cancer According to MET Alterations

Volume 129, Issue 1, Pages (July 2005)

Expression of LKB1 tumor suppressor in non–small cell lung cancer determines sensitivity to 2-deoxyglucose Landon J. Inge, PhD, Keith D. Coon, PhD, Michael.

Laminin γ2 Mediates Wnt5a-Induced Invasion of Gastric Cancer Cells

Volume 8, Issue 6, Pages (September 2014)

Pioglitazone inhibits aromatase expression in human preadipocytes.

Volume 16, Issue 6, Pages (December 2009)

A20 inhibits caspase-8 cleavage and TRAIL-induced apoptosis.

Volume 139, Issue 3, Pages e6 (September 2010)

ABIN-1 inhibits IL-17–dependent NF-κB activation.

A, left: indicated MEFs were transfected as described in the Methods section. A, left: indicated MEFs were transfected as described in the Methods section.

Peroxynitrite Production, DNA Breakage, and Poly(ADP-ribose) Polymerase Activation in a Mouse Model of Oxazolone-Induced Contact Hypersensitivity Éva.

Volume 26, Issue 2, Pages (August 2014)

The selective PI3K inhibitor A66 suppresses PIP3 accumulation, AKT phosphorylation at Thr308, and YAP/TAZ–regulated gene expression in PDAC cells. The.

3-O-Formyl-20R,21-epoxyresibufogenin suppresses IL-6–type cytokine actions by targeting the glycoprotein 130 subunit: Potential clinical implications

SPRY2 deficiency‐induced IL6 drives CRPC by elevating tumoral HSD3B1 and cholesterol levels SPRY2 deficiency‐induced IL6 drives CRPC by elevating tumoral.

AKT2, but not AKT1, is required for regulating survival of PTEN-deficient prostate tumor spheroids. AKT2, but not AKT1, is required for regulating survival.

Allopurinol up-regulates DR5 expression in PC-3 and DU145 cells.

Volume 114, Issue 5, Pages (May 1998)

(fold of TGF-β1 response)

BEZ235 induces MAPK signaling in a FOXO3A-dependent manner.

BCR–ABL kinase activity rewires GM-CSFR signaling and confers oncogene addiction in TF1 cells. BCR–ABL kinase activity rewires GM-CSFR signaling and confers.

BCX inhibits lamellipodia formation in lung cells.

The sesquiterpene lactone PN up-regulates MDM2 and p53 proteins.

JAK inhibitors suppress IL-17–induced expression of IκB-ζ.

A, IGFBP-3 knockdown via siRNA using real-time qRT-PCR analysis.

Induction of CDCP1 is regulated by Ras in NSCLC cells.

The role of p53 in H2O2-mediated cell death of hOGG1-deficient H1299 lung carcinoma p53 null cells. The role of p53 in H2O2-mediated cell death of hOGG1-deficient.

Figure 4. EC-18 dephosphorylated activated STAT6

Treatment effects of fenretinide (4-HPR, 5 μmol/L), 2-ME (2

Socially isolated SV40 Tag mice develop significantly larger mammary gland tumors. Socially isolated SV40 Tag mice develop significantly larger mammary.

Mitotic catastrophe symptoms caused by curcumin are followed by apoptosis. Mitotic catastrophe symptoms caused by curcumin are followed by apoptosis. A.

Bcl-2 and caspase inhibition fails to inhibit BAMLET-induced cytotoxicity in MCF-7 cells. Bcl-2 and caspase inhibition fails to inhibit BAMLET-induced.

Immunohistochemistry for phosphorylated (S235) S6 ribosomal protein and quantitation of Ki67 labeling indices in vehicle- and WAY –treated Eker (Tsc2+/−)

The cross-talk between PARylation and phosphorylation.

N-3 PUFAs promote endometrial cancer cell apoptosis in vitro and in vivo. n-3 PUFAs promote endometrial cancer cell apoptosis in vitro and in vivo. HEC-1-A.

Effect of GSK3β inhibition on cell survival and proliferation of glioblastoma cells. Effect of GSK3β inhibition on cell survival and proliferation of glioblastoma.

Endogenously produced n-3 PUFAs inhibit endometrial cancer cell growth in vitro and in vivo. Endogenously produced n-3 PUFAs inhibit endometrial cancer.

NKT cell recognition of CD1d1 molecules is inhibited by treatment with ascites. NKT cell recognition of CD1d1 molecules is inhibited by treatment with.

A combination of neurotensin and insulin potently decreases YAP phosphorylation at Ser127 and Ser397 in PDAC cells. A combination of neurotensin and insulin.

Effect of CDV on human SF7796 xenografts in vivo.

Impact of eNOS expression and treatment with GSNO on prostate tumor growth. Impact of eNOS expression and treatment with GSNO on prostate tumor growth.

Induction of apoptosis by statins in NB4 cells and NB4 variant cell lines. Induction of apoptosis by statins in NB4 cells and NB4 variant cell lines. A,

AS1411 alters subcellular distribution of PRMT5 in a time-dependent, dose-dependent, and nucleolin-dependent manner. AS1411 alters subcellular distribution.

CHL-induced apoptosis in HCT116 cells involves the activation of procaspase-8 and procaspase-6, with cleavage of nuclear lamins. CHL-induced apoptosis.

Induction of PARP cleavage (A) and activation of caspases (B) after treatment with a combination of TRAIL and cisplatin. Induction of PARP cleavage (A)

Effect of MIF siRNA on the production of MMP-13 induced by LPA

W. chinensis extract induces apoptosis in AR-dependent prostate cancer cells. W. chinensis extract induces apoptosis in AR-dependent prostate cancer cells.

Sorafenib inhibits cell proliferation and induces apoptosis in HCC cells. Sorafenib inhibits cell proliferation and induces apoptosis in HCC cells. A,

Posttranslational phosphorylation of p53 by platinum drugs in ovarian tumor cells. Posttranslational phosphorylation of p53 by platinum drugs in ovarian.

Mechanism by which flavopiridol induces cell cycle arrest and apoptosis in rhabdoid tumor cells. Mechanism by which flavopiridol induces cell cycle arrest.

Elevated STAT3 phosphorylation and RANTES levels in tamoxifen-treated breast cancer cells. Elevated STAT3 phosphorylation and RANTES levels in tamoxifen-treated.

A, indicated model systems were cultured in media containing complete serum, harvested, and lysed; total protein was separated by SDS-PAGE, transferred.

IL-17 signaling upregulates ABIN-1 mRNA but downregulates protein.

I3C reduces the level of Cdc25A protein in breast cancer cells.

Effect of 6-SHO on mouse prostate cancer HMVP2 cells.

DHA and dietary n-3 PUFAs inhibit endometrial cancer cell growth in vitro and in xenograft models. DHA and dietary n-3 PUFAs inhibit endometrial cancer.

Presentation transcript:

A, analysis of cytoplasmic histone-associated DNA fragmentation in LNCaP cells following 24-h cotreatment with the indicated concentrations of SFN and 10 ng/mL IL-6. A, analysis of cytoplasmic histone-associated DNA fragmentation in LNCaP cells following 24-h cotreatment with the indicated concentrations of SFN and 10 ng/mL IL-6. Columns, mean (n = 3); bars, SE. Significantly different (P < 0.05) compared with respective DMSO-treated control (a) and DNA fragmentation in the absence of IL-6 stimulation (b) by one-way ANOVA followed by Bonferroni's multiple comparison test. B, immunoblotting for pSTAT3, cleaved poly(ADP-ribose) polymerase (PARP), and cleaved caspase-3 using lysates from LNCaP cells following 24-h treatment with the indicated concentrations of SFN in the presence or absence of 10 ng/mL IL-6 (24-h treatment). C, analysis of cytoplasmic histone-associated DNA fragmentation in DU145 cells transiently transfected with a control nonspecific siRNA or STAT3-targeted siRNA and treated for 24 h with DMSO (control) or 40 μmol/L SFN. Inset, immunoblotting for total STAT3 in cells transiently transfected with the nonspecific siRNA (lane 1) and the STAT3-targeted siRNA (lane 2). Columns, mean (n = 3); bars, SE. *, P < 0.05, significantly different between the indicated groups by one-way ANOVA followed by Bonferroni's multiple comparison test. Each experiment was repeated at least twice, and representative data from one such experiment are shown. D, immunoblotting for total STAT3/JAK2 and pSTAT3 using supernatants from three representative prostate tumors harvested from control and SFN-treated TRAMP mice (15). Eun-Ryeong Hahm, and Shivendra V. Singh Cancer Prev Res 2010;3:484-494 ©2010 by American Association for Cancer Research