Cartilage T1ρ and T2 relaxation times: longitudinal reproducibility and variations using different coils, MR systems and sites X. Li, V. Pedoia, D. Kumar,

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Cartilage T1ρ and T2 relaxation times: longitudinal reproducibility and variations using different coils, MR systems and sites X. Li, V. Pedoia, D. Kumar, J. Rivoire, C. Wyatt, D. Lansdown, K. Amano, N. Okazaki, D. Savic, M.F. Koff, J. Felmlee, S.L. Williams, S. Majumdar Osteoarthritis and Cartilage Volume 23, Issue 12, Pages 2214-2223 (December 2015) DOI: 10.1016/j.joca.2015.07.006 Copyright © 2015 Osteoarthritis Research Society International Terms and Conditions

Fig. 1 Flow chart of the single-site and multi-site studies. Osteoarthritis and Cartilage 2015 23, 2214-2223DOI: (10.1016/j.joca.2015.07.006) Copyright © 2015 Osteoarthritis Research Society International Terms and Conditions

Fig. 2 Longitudinal reproducibility of T1ρ (A) and T2 (B) values in a phantom with 3% agarose (weight/volume, %) measured from September 2011 (11-9) through July 2014 (14-7) using GE 3T MR systems: HDx long bore (HDx LB), MR750 wide bore (MR750W) and MR750. Cross-sectional variations in T1ρ (C) and T2 (D) values in phantoms using four different models of GE 3T MR systems. Osteoarthritis and Cartilage 2015 23, 2214-2223DOI: (10.1016/j.joca.2015.07.006) Copyright © 2015 Osteoarthritis Research Society International Terms and Conditions

Fig. 3 Variations in in vivo T1ρ (A) and T2 (B) values and Bland–Altman plots of T1ρ (C) and T2 (D) values using different MR systems. T1ρ and T2 measured using the HDx Long Bore were significantly higher than those measured using the MR750 wide bore. Osteoarthritis and Cartilage 2015 23, 2214-2223DOI: (10.1016/j.joca.2015.07.006) Copyright © 2015 Osteoarthritis Research Society International Terms and Conditions

Fig. 4 Variations in in vivo T1ρ (A) and T2 (B) values and Bland–Altman plots of T1ρ (C) and T2 (D) values using different coils. T1ρ and T2 measured using the 16PAR flex coil were significantly higher than those measured using the QT8PAR knee coil. Osteoarthritis and Cartilage 2015 23, 2214-2223DOI: (10.1016/j.joca.2015.07.006) Copyright © 2015 Osteoarthritis Research Society International Terms and Conditions

Fig. 5 In vivo scan/re-scan reproducibility of cartilage T1ρ and T2 values of the multi-center study. (A) Overall CVs and CVs for each site; (B) CVs for each compartment. Osteoarthritis and Cartilage 2015 23, 2214-2223DOI: (10.1016/j.joca.2015.07.006) Copyright © 2015 Osteoarthritis Research Society International Terms and Conditions