Mineralocorticoid selectivity: Molecular and cellular aspects

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Presentation transcript:

Mineralocorticoid selectivity: Molecular and cellular aspects Dr Nicolette Farman, Brigitte Bocchi Kidney International Volume 57, Issue 4, Pages 1364-1369 (April 2000) DOI: 10.1046/j.1523-1755.2000.00976.x Copyright © 2000 International Society of Nephrology Terms and Conditions

Figure 1 Corticosteroid hormones, their plasma levels, affinity for mineralocorticoid receptors (MR) and glucocorticoid receptors (GR), and the number of receptors per aldosterone renal target cell. Kidney International 2000 57, 1364-1369DOI: (10.1046/j.1523-1755.2000.00976.x) Copyright © 2000 International Society of Nephrology Terms and Conditions

Figure 2 Schematic representation of mineralocorticoid receptors (MR), glucocorticoid receptors (GR), and 11β-hydroxysteroid dehydrogenase-2 (HSD2) expression along the mammalian nephron. The black zone represents the sites of high expression of GR, HSD2 (in rabbit, mouse, and humans), and MR [in rabbit; in the rat, the cortical portion of Henle's loop (tal) also expresses high levels of MR and HSD2]. Abbreviations are: pt, proximal tubule; dct, distal tubule; cd, collecting duct. Kidney International 2000 57, 1364-1369DOI: (10.1046/j.1523-1755.2000.00976.x) Copyright © 2000 International Society of Nephrology Terms and Conditions