Dawn H. Loh, Takashi Kudo, Christopher S. Colwell Neuron

Slides:

Advertisements

Similar presentations

Structure of a Ubiquitin E1-E2 Complex: Insights to E1-E2 Thioester Transfer Shaun K. Olsen, Christopher D. Lima Molecular Cell Volume 49, Issue 5, Pages.

Advertisements

Expectation Modulates Neural Responses to Pleasant and Aversive Stimuli in Primate Amygdala Marina A. Belova, Joseph J. Paton, Sara E. Morrison, C. Daniel.

Individualized Medicine from Prewomb to Tomb Eric J. Topol Cell Volume 157, Issue 1, Pages (March 2014) DOI: /j.cell Copyright.

The Neurobiology of Decision: Consensus and Controversy Joseph W. Kable, Paul W. Glimcher Neuron Volume 63, Issue 6, Pages (September 2009) DOI:

Trial Outcome and Associative Learning Signals in the Monkey Hippocampus Sylvia Wirth, Emin Avsar, Cindy C. Chiu, Varun Sharma, Anne C. Smith, Emery Brown,

Treating the Developing versus Developed Brain: Translating Preclinical Mouse and Human Studies B.J. Casey, Charles E. Glatt, Francis S. Lee Neuron Volume.

Preference Distributions of Primary Motor Cortex Neurons Reflect Control Solutions Optimized for Limb Biomechanics Timothy P. Lillicrap, Stephen H. Scott.

The Pathobiology of Vascular Dementia Costantino Iadecola Neuron Volume 80, Issue 4, Pages (November 2013) DOI: /j.neuron Copyright.

Intensity-Dependent Adaptation of Cortical and Thalamic Neurons Is Controlled by Brainstem Circuits of the Sensory Pathway Elad Ganmor, Yonatan Katz, Ilan.

Decision Making as a Window on Cognition Michael N. Shadlen, Roozbeh Kiani Neuron Volume 80, Issue 3, Pages (October 2013) DOI: /j.neuron

Contour Saliency in Primary Visual Cortex Wu Li, Valentin Piëch, Charles D. Gilbert Neuron Volume 50, Issue 6, Pages (June 2006) DOI: /j.neuron

The Local Transcriptome in the Synaptic Neuropil Revealed by Deep Sequencing and High-Resolution Imaging Iván J. Cajigas, Georgi Tushev, Tristan J. Will,

Auditory Hair Cell-Afferent Fiber Synapses Are Specialized to Operate at Their Best Frequencies M.E. Schnee, D.M. Lawton, D.N. Furness, T.A. Benke, A.J.

Neuronal Cell Types and Connectivity: Lessons from the Retina H. Sebastian Seung, Uygar Sümbül Neuron Volume 83, Issue 6, Pages (September 2014)

Molecular Motors in Neurons: Transport Mechanisms and Roles in Brain Function, Development, and Disease Nobutaka Hirokawa, Shinsuke Niwa, Yosuke Tanaka.

Synapse-Specific Adaptations to Inactivity in Hippocampal Circuits Achieve Homeostatic Gain Control while Dampening Network Reverberation Jimok Kim, Richard.

Pyramidal Neurons Grow Up and Change Their Mind Gord Fishell, Carina Hanashima Neuron Volume 57, Issue 3, Pages (February 2008) DOI: /j.neuron

Hippocampal Activity Patterns Carry Information about Objects in Temporal Context Liang-Tien Hsieh, Matthias J. Gruber, Lucas J. Jenkins, Charan Ranganath.

The Mitochondrial Basis of Aging Nuo Sun, Richard J. Youle, Toren Finkel Molecular Cell Volume 61, Issue 5, Pages (March 2016) DOI: /j.molcel

Dissociable Medial Prefrontal Contributions to Judgments of Similar and Dissimilar Others Jason P. Mitchell, C. Neil Macrae, Mahzarin R. Banaji Neuron.

Mechanisms of Age-Related Macular Degeneration Jayakrishna Ambati, Benjamin J. Fowler Neuron Volume 75, Issue 1, Pages (July 2012) DOI: /j.neuron

Adaptation to Natural Binocular Disparities in Primate V1 Explained by a Generalized Energy Model Ralf M. Haefner, Bruce G. Cumming Neuron Volume 57, Issue.

Reading the Book of Memory: Sparse Sampling versus Dense Mapping of Connectomes H. Sebastian Seung Neuron Volume 62, Issue 1, Pages (April 2009)

Rare Inherited Variation in Autism: Beginning to See the Forest and a Few Trees Jason L. Stein, Neelroop N. Parikshak, Daniel H. Geschwind Neuron Volume.

Dissecting the Pathophysiology of Depression with a Swiss Army Knife

Organization of the Drosophila Circadian Control Circuit

A Molecular Code for Imprinting Drug-Cue Associations

A Time to Divide: Does the Circadian Clock Control Cell Cycle?

PDF Has Found Its Receptor

Volume 95, Issue 1, Pages 6-8 (July 2017)

Volume 49, Issue 1, Pages 1-2 (January 2006)

Parkinson’s Disease: A Thalamostriatal Rebalancing Act?

Zoltán Molnár, Elek Molnár Neuron

Should I Stay or Should I Go: Neuromodulators of Behavioral States

“MAPseq”-uencing Long-Range Neuronal Projections

Can One Suppress Subliminal Words?

Silent Synapses Sit and Wait for a Better Day

Dissonant Synapses Shall Be Punished

New Neurons Don’t Talk Back

The Emerging Field of Neuroepigenetics

Volume 85, Issue 5, Pages (March 2015)

There's More Than One Way to Scale a Synapse

Applying the Brakes: When to Stop Eating

Volume 68, Issue 2, Pages (October 2010)

Following Directions from the Retina to the Brain

Volume 55, Issue 3, Pages (August 2007)

Huntington's Disease: Can Mice Lead the Way to Treatment?

Recurrent Feedback Loops in Associative Learning

Making Choices between Rules or between Actions

Julien Courchet, Franck Polleux Neuron

Simons Variation in Individuals Project (Simons VIP): A Genetics-First Approach to Studying Autism Spectrum and Related Neurodevelopmental Disorders

Bringing Kids into the Scientific Review Process

Learning about Synaptic GluA3

K+ Channel Regulation of Multicompartmental Signal Integration

Aligning a Synapse Neuron

Timing Rules for Synaptic Plasticity Matched to Behavioral Function

Protected by a Fox Neuron Volume 98, Issue 1, Pages 3-5 (April 2018)

Volume 91, Issue 6, Pages (September 2016)

Beta and Gamma Rhythms Go with the Flow

Volume 97, Issue 1, Pages (January 2018)

The Cell Biology of Genomes: Bringing the Double Helix to Life

Superior Colliculus Does Play Dice

Enigmas of the Dentate Gyrus

The Cost of Brain Diseases: A Burden or a Challenge?

The Mysterious Motivational Functions of Mesolimbic Dopamine

Gerald D. Fischbach, Catherine Lord Neuron

David Hubel and Torsten Wiesel

Bringing Optogenetics to the Synapse

Biological Functions of Activity-Dependent Transcription Revealed

Opening a “Wide” Window onto Taste Signal Transmission

Presentation transcript:

Short Circuiting the Circadian System with a New Generation of Precision Tools Dawn H. Loh, Takashi Kudo, Christopher S. Colwell Neuron Volume 85, Issue 5, Pages 895-898 (March 2015) DOI: 10.1016/j.neuron.2015.02.037 Copyright © 2015 Elsevier Inc. Terms and Conditions

Figure 1 Schematic Illustrating the Key Findings In this highly stylized representation, AVP-expressing neurons are localized in the shell region of the SCN while NMS-expressing neurons are localized throughout the nucleus. NMS (blue) appear to be co-expressed with the majority of AVP (green) and VIP (orange) expressing neurons. Disrupting the molecular clock in NMS or AVP neurons produced abnormal circadian rhythms. Lengthening the intracellular circadian period of NMS neurons lengthens behavioral circadian period. Blocking synaptic transmission from NMS neurons similarly leads to the loss of coherent circadian rhythms. These phenotypes were reversible with appropriate genetic manipulations. Neuron 2015 85, 895-898DOI: (10.1016/j.neuron.2015.02.037) Copyright © 2015 Elsevier Inc. Terms and Conditions