Measurement of structure (disease) modification in osteoarthritis

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Measurement of structure (disease) modification in osteoarthritis R.D. Altman Osteoarthritis and Cartilage Volume 12, Pages 69-76 (January 2004) DOI: 10.1016/j.joca.2003.09.011

Fig. 1 Results of long-term study of GP-C in 112 pairs of patients treated with GP-C and or vitamin B12(control). K-L 1-2: JSW: Bars represent percentage decrease from baseline in joint space width (JSW) after 16 years of treatment with GP-C (N=35) or vitamin B12(control; N=35). The change from baseline was significantly greater in the control group than in the GP-C group (P<0.05). THP: Bars represent the number of patients in the GP-C group (N=112) and vitamin B12(N=112) group who required total hip replacement (THP) over the course of the 16-year study. Osteoarthritis and Cartilage 2004 12, 69-76DOI: (10.1016/j.joca.2003.09.011)

Fig. 2 Degree of narrowing of medial joint space width in patients with knee OA who received symptomatic treatment only (control, N=42); GP-C (N=47); or GAGPS (N=41). Mean values are expressed as scores: 0=normal to 5=joint cavity absent (based on data presented in Rejholec, 1987). Osteoarthritis and Cartilage 2004 12, 69-76DOI: (10.1016/j.joca.2003.09.011)

Fig. 3 Mean hip joint space width (mm) at baseline and at the end of treatment with placebo (N=59) or GP-C (N=58) and change (mm) from baseline in hip joint space width at the end of treatment. Osteoarthritis and Cartilage 2004 12, 69-76DOI: (10.1016/j.joca.2003.09.011)

Fig. 4 Mean knee joint space width (mm) at baseline and at the end of treatment with placebo (N=139) or GP-C (N=138) and change (mm) from baseline in knee joint space width at the end of treatment. Osteoarthritis and Cartilage 2004 12, 69-76DOI: (10.1016/j.joca.2003.09.011)

Fig. 5 Percentage of patients treated with placebo (N=225) or diacerein (N=221) for 5-years who had radiographic progression (decrease from baseline in joint space width of at least 0.5mm). Osteoarthritis and Cartilage 2004 12, 69-76DOI: (10.1016/j.joca.2003.09.011)

Fig. 6 Percentages of patients treated with placebo (N=106) or glucosamine sulphate (GSO4) (N=106) for 3 years who had joint space narrowing of more than 0.5mm. Osteoarthritis and Cartilage 2004 12, 69-76DOI: (10.1016/j.joca.2003.09.011)