Combined Analysis of V20, VS5, Pulmonary Fibrosis Score on Baseline Computed Tomography, and Patient Age Improves Prediction of Severe Radiation Pneumonitis.

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Presentation transcript:

Combined Analysis of V20, VS5, Pulmonary Fibrosis Score on Baseline Computed Tomography, and Patient Age Improves Prediction of Severe Radiation Pneumonitis After Concurrent Chemoradiotherapy for Locally Advanced Non–Small-Cell Lung Cancer Kayoko Tsujino, MD, PhD, Tomohisa Hashimoto, MD, Temiko Shimada, MD, PhD, Eisaku Yoden, MD, PhD, Osamu Fujii, MD, PhD, Yosuke Ota, MD, Miyako Satouchi, MD, PhD, Shunichi Negoro, MD, Shuji Adachi, MD, PhD, Toshinori Soejima, MD, PhD Journal of Thoracic Oncology Volume 9, Issue 7, Pages 983-990 (July 2014) DOI: 10.1097/JTO.0000000000000187 Copyright © 2014 International Association for the Study of Lung Cancer Terms and Conditions

FIGURE 1 Definition of the computed tomography (CT) scoring system together with specific examples. The score can be determined when at least one lobe shows the relevant CT findings. A) Pulmonary fibrosis score and typical examples of scores 1, 2, and 3. B) Pulmonary emphysema score and typical examples of scores 2, 3, and 4. Journal of Thoracic Oncology 2014 9, 983-990DOI: (10.1097/JTO.0000000000000187) Copyright © 2014 International Association for the Study of Lung Cancer Terms and Conditions

FIGURE 2 Cumulative incidence curves of grade 3 or greater radiation pneumonitis stratified by the predictive risk score calculated from V20, VS5, age, and the pulmonary fibrosis score of the baseline computed tomography scan. Journal of Thoracic Oncology 2014 9, 983-990DOI: (10.1097/JTO.0000000000000187) Copyright © 2014 International Association for the Study of Lung Cancer Terms and Conditions

FIGURE 3 Receiving operator characteristic curve based on the sensitivity and specificity of V20 alone, V20 and VS5 combined, or all four factors combined (V20, VS5, age, and pulmonary fibrosis score of baseline computed tomography scan). Journal of Thoracic Oncology 2014 9, 983-990DOI: (10.1097/JTO.0000000000000187) Copyright © 2014 International Association for the Study of Lung Cancer Terms and Conditions