Volume 58, Issue 5, Pages (November 2000)

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Volume 58, Issue 5, Pages 1973-1979 (November 2000) Components of normal serum block the focal segmental glomerulosclerosis factor activity in vitro Ram Sharma, Mukut Sharma, Ellen T. McCarthy, Xiu-Li Ge, Virginia J. Savin Kidney International Volume 58, Issue 5, Pages 1973-1979 (November 2000) DOI: 10.1111/j.1523-1755.2000.00369.x Copyright © 2000 International Society of Nephrology Terms and Conditions

Figure 1 Dose response of the blocking effect of normal serum on focal segmental glomerulosclerosis (FSGS) serum-mediated increase in glomerular albumin permeability (Palb). Relative concentration of normal to FSGS serum of at least 1:1 is required to prevent increased Palb. Values for Palb are expressed as mean ± SD. The asterisk indicates different from glomeruli incubated with FSGS serum alone at P < 0.001. Kidney International 2000 58, 1973-1979DOI: (10.1111/j.1523-1755.2000.00369.x) Copyright © 2000 International Society of Nephrology Terms and Conditions

Figure 2 Effect of sequential incubation with normal and FSGS serum on Palb. Preincubation of isolated rat glomeruli with normal serum is required to protect them from the increase in Palb caused by FSGS serum. Values for Palb are expressed as mean ± SD. The asterisk indicates different from glomeruli incubated with normal serum alone or preincubated with normal serum prior to incubation with FSGS at P < 0.001. Kidney International 2000 58, 1973-1979DOI: (10.1111/j.1523-1755.2000.00369.x) Copyright © 2000 International Society of Nephrology Terms and Conditions

Figure 3 Electrophoretic pattern of proteins in the enriched fractions of normal, FSGS, and a 1:1 mix of normal with FSGS plasma. Gel electrophoresis was performed under nondenaturing and nonreducing conditions, and proteins were stained using silver staining. Lane 1, 80% precipitate of normal plasma. Lane 2, 80% precipitate of FSGS plasma. Lane 3, a 1:1 mix of 80% precipitate of FSGS and normal plasma. Kidney International 2000 58, 1973-1979DOI: (10.1111/j.1523-1755.2000.00369.x) Copyright © 2000 International Society of Nephrology Terms and Conditions