Volume 74, Issue 5, Pages (September 2008)

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Volume 74, Issue 5, Pages 641-648 (September 2008) Renal safety of annual zoledronic acid infusions in osteoporotic postmenopausal women Steven Boonen, Deborah E. Sellmeyer, Kurt Lippuner, Alexander Orlov-Morozov, Ken Abrams, Peter Mesenbrink, Erik F. Eriksen, Paul D. Miller Kidney International Volume 74, Issue 5, Pages 641-648 (September 2008) DOI: 10.1038/ki.2008.193 Copyright © 2008 International Society of Nephrology Terms and Conditions

Figure 1 Mean serum creatinine levels from baseline to 36 months in patients with pre- to post-infusion change of >0.5mg/100ml. For each infusion, the patients treated with 5mg of zoledronic acid showed similar mean serum creatinine levels at 9–11 days post-infusion and also at 12 months post-infusion. Kidney International 2008 74, 641-648DOI: (10.1038/ki.2008.193) Copyright © 2008 International Society of Nephrology Terms and Conditions

Figure 2 Long-term renal safety: mean change in estimated creatinine clearance from baseline to 36 months (safety population). At month 36, the mean (±s.e.m.) decrease from baseline in estimated creatinine clearance was similar in the patients treated with 5mg of zoledronic acid (−8.75±0.175ml/min) and in the placebo group (−8.67±0.175ml/min). Kidney International 2008 74, 641-648DOI: (10.1038/ki.2008.193) Copyright © 2008 International Society of Nephrology Terms and Conditions

Figure 3 Renal safety monitoring schedule during the HORIZON-PFT study. Kidney International 2008 74, 641-648DOI: (10.1038/ki.2008.193) Copyright © 2008 International Society of Nephrology Terms and Conditions