Determinants of glomerular hypofiltration in aging humans

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Presentation transcript:

Determinants of glomerular hypofiltration in aging humans Khoi Hoang, Jane C. Tan, Geraldine Derby, Kristina L. Blouch, Marilyn Masek, Irene Ma, Kevin V. Lemley, Bryan D. Myers Kidney International Volume 64, Issue 4, Pages 1417-1424 (October 2003) DOI: 10.1046/j.1523-1755.2003.00207.x Copyright © 2003 International Society of Nephrology Terms and Conditions

Figure 1 Glomerular filtration rate (GFR) plotted as a function of age in 164 healthy individuals. Symbols are: (○) males; (▴) females. Kidney International 2003 64, 1417-1424DOI: (10.1046/j.1523-1755.2003.00207.x) Copyright © 2003 International Society of Nephrology Terms and Conditions

Figure 2 Renal plasma flow (RPF) (A) as a function of age and mean arterial pressure (MAP) (B) as a function of age. Kidney International 2003 64, 1417-1424DOI: (10.1046/j.1523-1755.2003.00207.x) Copyright © 2003 International Society of Nephrology Terms and Conditions

Figure 3 Two-kidney ultrafiltration coefficient (Kf) for ΔP = 40mm Hg in youthful (<40 years) and ΔP = 40 or 45mm Hg in aging subjects (≥55 years).*P < 0.005 vs. youthful. Kidney International 2003 64, 1417-1424DOI: (10.1046/j.1523-1755.2003.00207.x) Copyright © 2003 International Society of Nephrology Terms and Conditions

Figure 4 Percent of global glomerulosclerosis in biopsies of youthful (<40 years) and aging (≥55 years) healthy subjects. Kidney International 2003 64, 1417-1424DOI: (10.1046/j.1523-1755.2003.00207.x) Copyright © 2003 International Society of Nephrology Terms and Conditions

Figure 5 Filtration slit frequency (FSF) (A) and filtration surface density (SV) (B) as a function of age in healthy subjects. Kidney International 2003 64, 1417-1424DOI: (10.1046/j.1523-1755.2003.00207.x) Copyright © 2003 International Society of Nephrology Terms and Conditions

Figure 6 Hydraulic permeability (k) (A), filtration surface area (S) (B), and single-nephron ultrafiltration coefficient (SNKf) (C) in youthful (<40 years) vs. aging (≥55 years) subjects.*P < 0.05; †P = 0.09 vs. youthful group. Kidney International 2003 64, 1417-1424DOI: (10.1046/j.1523-1755.2003.00207.x) Copyright © 2003 International Society of Nephrology Terms and Conditions