Sandhia Naik, Fabienne Smith, John Ho, Nicholas M

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Presentation transcript:

Staphylococcal Enterotoxins G and I, a Cause of Severe but Reversible Neonatal Enteropathy  Sandhia Naik, Fabienne Smith, John Ho, Nicholas M. Croft, Paola Domizio, Elisabeth Price, Ian R. Sanderson, Nigel J. Meadows  Clinical Gastroenterology and Hepatology  Volume 6, Issue 2, Pages 251-254 (February 2008) DOI: 10.1016/j.cgh.2007.09.004 Copyright © 2008 AGA Institute Terms and Conditions

Figure 1 Infant 1: duodenal biopsy specimen. H&E staining at high power shows marked villous atrophy and a dense inflammatory infiltrate in the lamina propria. (Color version of this figure is available online at www.cghjournal.org.) Clinical Gastroenterology and Hepatology 2008 6, 251-254DOI: (10.1016/j.cgh.2007.09.004) Copyright © 2008 AGA Institute Terms and Conditions

Figure 2 Infant 1: EM of duodenal biopsy specimen. EM 24,000× shows loss of microvilli, cytoplasmic vacuolation, no secretary granules, and no inclusion bodies. Clinical Gastroenterology and Hepatology 2008 6, 251-254DOI: (10.1016/j.cgh.2007.09.004) Copyright © 2008 AGA Institute Terms and Conditions

Figure 3 Infant 2: duodenal biopsy specimen. H&E staining at low power shows marked villous atrophy and a dense inflammatory infiltrate in the lamina propria with crypt hyperplasia. (Color version of this figure is available online at www.cghjournal.org.) Clinical Gastroenterology and Hepatology 2008 6, 251-254DOI: (10.1016/j.cgh.2007.09.004) Copyright © 2008 AGA Institute Terms and Conditions

Figue 4 Infant 2: duodenal biopsy specimen. Periodic acid–Schiff staining showing abnormal/absent accumulation of brush-border membrane material. (Color version of this figure is available online at www.cghjournal.org.) Clinical Gastroenterology and Hepatology 2008 6, 251-254DOI: (10.1016/j.cgh.2007.09.004) Copyright © 2008 AGA Institute Terms and Conditions

Figure 5 Infant 2: EM of duodenal biopsy specimen. EM 24,000× shows short, stunted, abnormal microvilli, dilated mitochondria, lysosymes with cellular debris, and no inclusion bodies. Clinical Gastroenterology and Hepatology 2008 6, 251-254DOI: (10.1016/j.cgh.2007.09.004) Copyright © 2008 AGA Institute Terms and Conditions

Figure 6 Infant 2: EM of duodenal biopsy specimen. Three months after PN and intravenous antibiotics, a return to normal microvillous architecture was seen. Clinical Gastroenterology and Hepatology 2008 6, 251-254DOI: (10.1016/j.cgh.2007.09.004) Copyright © 2008 AGA Institute Terms and Conditions