Assessment of Therapy Responses and Prediction of Survival in Malignant Pleural Mesothelioma Through Computer-Aided Volumetric Measurement on Computed.

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Assessment of Therapy Responses and Prediction of Survival in Malignant Pleural Mesothelioma Through Computer-Aided Volumetric Measurement on Computed Tomography Scans Fan Liu, PhD, Binsheng Zhao, DSc, Lee M. Krug, MD, Nicole M. Ishill, MS, Remy C. Lim, MD, Pingzhen Guo, MD, Matthew Gorski, BA, Raja Flores, MD, Chaya S. Moskowitz, PhD, Valerie W. Rusch, MD, Lawrence H. Schwartz, MD Journal of Thoracic Oncology Volume 5, Issue 6, Pages 879-884 (June 2010) DOI: 10.1097/JTO.0b013e3181dd0ef1 Copyright © 2010 International Association for the Study of Lung Cancer Terms and Conditions

FIGURE 1 Circumferential and irregular shape of malignant pleural mesothelioma showed limitations of 2D measurement (arrows). Journal of Thoracic Oncology 2010 5, 879-884DOI: (10.1097/JTO.0b013e3181dd0ef1) Copyright © 2010 International Association for the Study of Lung Cancer Terms and Conditions

FIGURE 2 Computer segmentation of tumor corrected by radiologist. A, computer result on original image with suboptimal segmentation and inclusion of other tissues (arrows). B, manual correction on computer result. C and D, 3D rendering of the baseline alignant pleural mesothelioma (MPM) volume (596 cc) and the first follow-up MPM volume (208 cc). Journal of Thoracic Oncology 2010 5, 879-884DOI: (10.1097/JTO.0b013e3181dd0ef1) Copyright © 2010 International Association for the Study of Lung Cancer Terms and Conditions

FIGURE 3 Overall survival curve. Journal of Thoracic Oncology 2010 5, 879-884DOI: (10.1097/JTO.0b013e3181dd0ef1) Copyright © 2010 International Association for the Study of Lung Cancer Terms and Conditions

FIGURE 4 Survival analysis of baseline and early follow-up. A, patients with small MPM volume in baseline tends to survival longer (p = 0.07). B, patients whose MPM volume decreased in early follow-up and longer survival (p = 0.03). Journal of Thoracic Oncology 2010 5, 879-884DOI: (10.1097/JTO.0b013e3181dd0ef1) Copyright © 2010 International Association for the Study of Lung Cancer Terms and Conditions