Kinesin and myosin: molecular motors with similar engines

Slides:

Advertisements

Similar presentations

Volume 10, Issue 8, Pages (August 2002)

Advertisements

Structure of the Rho Family GTP-Binding Protein Cdc42 in Complex with the Multifunctional Regulator RhoGDI Gregory R. Hoffman, Nicolas Nassar, Richard.

Structure of the Rho Transcription Terminator

R.Ian Menz, John E. Walker, Andrew G.W. Leslie Cell

Volume 11, Issue 12, Pages (December 2003)

Structural Basis of the Redox Switch in the OxyR Transcription Factor

Volume 10, Issue 8, Pages (August 2002)

Structure and Protein Design of a Human Platelet Function Inhibitor

Structure of an LDLR-RAP Complex Reveals a General Mode for Ligand Recognition by Lipoprotein Receptors Carl Fisher, Natalia Beglova, Stephen C. Blacklow

Crystal Structure of Maltose Phosphorylase from Lactobacillus brevis

Volume 124, Issue 1, Pages (January 2006)

Transcription: Identification of a prime suspect

Volume 9, Issue 9, Pages (September 2001)

Volume 23, Issue 6, Pages (September 2006)

Volume 21, Issue 4, Pages (April 2013)

Mark Ultsch, Nathalie A Lokker, Paul J Godowski, Abraham M de Vos

Bypassing Translation Initiation

The Mechanism of E. coli RNA Polymerase Regulation by ppGpp Is Suggested by the Structure of their Complex Yuhong Zuo, Yeming Wang, Thomas A. Steitz

Structure of a tRNA Repair Enzyme and Molecular Biology Workhorse

Fifty Ways to Love Your Lever: Myosin Motors

Volume 4, Issue 11, Pages (November 1996)

Structure of Cry2Aa Suggests an Unexpected Receptor Binding Epitope

Volume 4, Issue 5, Pages (November 1999)

Volume 91, Issue 7, Pages (December 1997)

Volume 19, Issue 5, Pages (September 2005)

Volume 93, Issue 1, Pages 5-8 (April 1998)

Crystal Structure of Recombinant Human Interleukin-22

15 Å Resolution Model of the Monomeric Kinesin Motor, KIF1A

Volume 124, Issue 5, Pages (March 2006)

Volume 90, Issue 1, Pages (July 1997)

Volume 15, Issue 11, Pages (November 2007)

Edith Schlagenhauf, Robert Etges, Peter Metcalf Structure

Volume 14, Issue 2, Pages (April 2004)

Volume 5, Issue 3, Pages (March 1997)

Volume 91, Issue 5, Pages (November 1997)

Crystal structure of the ternary complex of 1,3,8-trihydroxynaphthalene reductase from Magnaporthe grisea with NADPH and an active-site inhibitor Arnold.

Crystal Structure of the DegS Stress Sensor

Antonina Roll-Mecak, Chune Cao, Thomas E. Dever, Stephen K. Burley

Volume 6, Issue 6, Pages (December 2000)

Volume 90, Issue 2, Pages (July 1997)

Volume 14, Issue 8, Pages (August 2006)

Microtubule Interaction Site of the Kinesin Motor

Volume 91, Issue 7, Pages (December 1997)

Volume 6, Issue 1, Pages (July 2000)

Myosin structure: Does the tail wag the dog?

Volume 15, Issue 11, Pages (November 2007)

Volume 118, Issue 6, Pages (September 2004)

Structural Basis of Rab Effector Specificity

Volume 23, Issue 9, Pages (September 2015)

Volume 3, Issue 3, Pages (March 1995)

Silvia Onesti, Andrew D Miller, Peter Brick Structure

Structure of the Rho Family GTP-Binding Protein Cdc42 in Complex with the Multifunctional Regulator RhoGDI Gregory R. Hoffman, Nicolas Nassar, Richard.

Tertiary Structure of Destrin and Structural Similarity between Two Actin-Regulating Protein Families H Hatanaka, K Ogura, K Moriyama, S Ichikawa, I.

Volume 34, Issue 3, Pages (May 2009)

Amedeo Caflisch, Martin Karplus Structure

Volume 5, Issue 3, Pages (March 1997)

Structural Basis of Swinholide A Binding to Actin

The swinging lever-arm hypothesis of muscle contraction

Volume 9, Issue 2, Pages (February 2001)

Mark A Lemmon, Kathryn M Ferguson, Joseph Schlessinger Cell

A model of the microtubule–kinesin complex based on electron cryomicroscopy and X- ray crystallography Frank Kozielski, Isabelle Arnal, Richard H. Wade

Helicase structures: a new twist on DNA unwinding

Atomic Structure of Scallop Myosin Subfragment S1 Complexed with MgADP

Hammerhead ribozyme structure: U-turn for RNA structural biology

Volume 10, Issue 4, Pages (April 2003)

Volume 13, Issue 4, Pages (April 2005)

Volume 23, Issue 9, Pages (September 2015)

Wag the Tail: Structural Dynamics of Actomyosin

Structural and Biochemical Analysis of the Obg GTP Binding Protein

Thomas Kampourakis, Yin-Biao Sun, Malcolm Irving Biophysical Journal

Presentation transcript:

Kinesin and myosin: molecular motors with similar engines Ivan Rayment Structure Volume 4, Issue 5, Pages 501-504 (May 1996) DOI: 10.1016/S0969-2126(96)00055-X

Figure 1 Schematic representation of the architecture of (a) kinesin, (b) NCD (non-claret disjunctional) and (c) skeletal muscle myosin (myosin II). Two light chains are shown attached to the motor domain of myosin and these serve to increase the magnitude of the power stroke. Structure 1996 4, 501-504DOI: (10.1016/S0969-2126(96)00055-X)

Figure 2 Ribbon representations of (a) the kinesin motor domain and (b) the chicken skeletal myosin subfragment-1 [13]. They are oriented to look into the nucleotide-binding pocket which is identified by the location of ADP (ball-and-stick representation) in kinesin and a sulfate ion (space-filling model in red and yellow) that binds to the P-loop in myosin subfragment-1. The secondary structural elements in kinesin that are also found in myosin are colored in green (β strands) and dark blue (α helices) and the remainder of the myosin heavy chain is rendered in grey. Kinesin and myosin are drawn to similar scales. (a) was kindly provided by Jon Kull and Robert Fletterick and was modified from [2], with permission. Structure 1996 4, 501-504DOI: (10.1016/S0969-2126(96)00055-X)

Figure 2 Ribbon representations of (a) the kinesin motor domain and (b) the chicken skeletal myosin subfragment-1 [13]. They are oriented to look into the nucleotide-binding pocket which is identified by the location of ADP (ball-and-stick representation) in kinesin and a sulfate ion (space-filling model in red and yellow) that binds to the P-loop in myosin subfragment-1. The secondary structural elements in kinesin that are also found in myosin are colored in green (β strands) and dark blue (α helices) and the remainder of the myosin heavy chain is rendered in grey. Kinesin and myosin are drawn to similar scales. (a) was kindly provided by Jon Kull and Robert Fletterick and was modified from [2], with permission. Structure 1996 4, 501-504DOI: (10.1016/S0969-2126(96)00055-X)