Robert A. Wood, MD, Alkis Togias, MD, Jeremy Wildfire, MS, Cynthia M

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Presentation transcript:

Development of cockroach immunotherapy by the Inner-City Asthma Consortium Robert A. Wood, MD, Alkis Togias, MD, Jeremy Wildfire, MS, Cynthia M. Visness, PhD, Elizabeth C. Matsui, MD, MHS, Rebecca Gruchalla, MD, Gurjit Hershey, MD, Andrew H. Liu, MD, George T. O'Connor, MD, MS, Jacqueline A. Pongracic, MD, Edward Zoratti, MD, Frederic Little, MD, Mark Granada, MD, Suzanne Kennedy, PhD, Stephen R. Durham, MD, Mohamed H. Shamji, PhD, William W. Busse, MD Journal of Allergy and Clinical Immunology Volume 133, Issue 3, Pages 846-852.e6 (March 2014) DOI: 10.1016/j.jaci.2013.08.047 Copyright © 2013 Terms and Conditions

Fig 1 IgE and IgG4 levels and blocking antibody activity responses by study group. Average* biomarker levels by treatment arm in BioCSI (total n = 54, column 1), BioCSI2 (n = 89, column 2), and SCITCO (n = 10, column 3). Treatment effects for BioCSI and BioCSI2 are detailed in Table I. All 3 biomarkers showed significant change from baseline during the 6-month treatment period in SCITCO. *Geometric means are plotted for IgE and IgG4 levels and arithmetic means for blocking antibody activity. Journal of Allergy and Clinical Immunology 2014 133, 846-852.e6DOI: (10.1016/j.jaci.2013.08.047) Copyright © 2013 Terms and Conditions

Fig E1 German cockroach serum IgE levels by study visit for each BioCSI participant. Horizontal lines indicate baseline IgE levels and a 3-fold increase from baseline values. Shaded panels indicate that the participant depicted had a maximum IgE level that was at least 3 times greater than the baseline value. Journal of Allergy and Clinical Immunology 2014 133, 846-852.e6DOI: (10.1016/j.jaci.2013.08.047) Copyright © 2013 Terms and Conditions

Fig E2 German cockroach serum IgE levels by study visit for each BioCSI2 participant. Horizontal lines indicate baseline IgE levels and a 3-fold increase from baseline values. Shaded panels indicate that the participant depicted had a maximum IgE level that was at least 3 times greater than the baseline value. Journal of Allergy and Clinical Immunology 2014 133, 846-852.e6DOI: (10.1016/j.jaci.2013.08.047) Copyright © 2013 Terms and Conditions

Fig E3 German cockroach serum IgE levels by study visit for each SCITCO participant. Horizontal lines indicate baseline IgE levels and a 3-fold increase from baseline values. Shaded panels indicate that the participant depicted had a maximum IgE level that was at least 3 times greater than the baseline value. Journal of Allergy and Clinical Immunology 2014 133, 846-852.e6DOI: (10.1016/j.jaci.2013.08.047) Copyright © 2013 Terms and Conditions

Fig E4 German cockroach serum IgG4 levels by study visit for each SCITCO participant. Horizontal lines indicate baseline IgG4 levels and a 2-fold increase from baseline values. Shaded panels indicate a maximum IgG4 level that is at least 2 times greater than the baseline value. Journal of Allergy and Clinical Immunology 2014 133, 846-852.e6DOI: (10.1016/j.jaci.2013.08.047) Copyright © 2013 Terms and Conditions