Volume 69, Issue 2, Pages (January 2006)

Slides:

Advertisements

Similar presentations

Volume 56, Pages S238-S241 (July 1999)

Advertisements

Steven Fishbane, Jeffrey S. Berns, M.D. Kidney International

Beta blockers in the management of chronic kidney disease

Volume 70, Issue 8, Pages (October 2006)

Volume 56, Pages S54-S56 (July 1999)

Volume 71, Issue 11, Pages (June 2007)

Chronic lymphocytic leukemia and cryoglobulinemic glomerulonephritis

Naïve and central memory T-cell lymphopenia in end-stage renal disease

Volume 72, Issue 1, Pages (July 2007)

Treatment of early mixed cellular and humoral renal allograft rejection with tacrolimus and mycophenolate mofetil Q. Sun, Z-H. Liu, Z. Cheng, J. Chen,

Volume 69, Issue 1, Pages (January 2006)

Peritubular capillaritis in the renal allograft takes center stage

Apoptosis in the kidneys of patients with type II diabetic nephropathy

Volume 71, Issue 8, Pages (April 2007)

Volume 70, Pages S21-S25 (December 2006)

VEGF receptor 2 blockade leads to renal cyst formation in mice

H.B. Lee, H. Noh, J.Y. Seo, M.R. Yu, H. Ha Kidney International

Enlarged nephrons and severe nondiabetic nephropathy in hepatocyte nuclear factor-1β (HNF-1β) mutation carriers Jørn V. Sagen, Leif Bostad, Pål R. Njølstad,

Volume 70, Issue 11, Pages (December 2006)

D. Coyne Kidney International Volume 69, Pages S1-S3 (May 2006)

Volume 87, Issue 2, Pages (February 2015)

Volume 70, Issue 2, Pages (July 2006)

Volume 71, Issue 6, Pages (March 2007)

Volume 70, Issue 12, Pages (December 2006)

Volume 67, Pages S48-S51 (January 2005)

Blood pressure targets in hemodialysis patients

Volume 70, Issue 8, Pages (October 2006)

Fructose intake as a risk factor for kidney stone disease

Volume 73, Issue 9, Pages (May 2008)

The third World Kidney Day: Looking back and thinking forward

M. Mizobuchi, J.L. Finch, D.R. Martin, E. Slatopolsky

Volume 62, Issue 2, Pages (August 2002)

Volume 69, Issue 12, Pages (June 2006)

Volume 69, Issue 3, Pages (February 2006)

Kidney failure and the gut: p-cresol and the dangers from within

Environmental exposure to lead and progressive diabetic nephropathy in patients with type II diabetes J.-L. Lin, D.-T. Lin-Tan, C.-C. Yu, Y.-J. Li, Y.-Y.

Alfonso M. Cueto-Manzano, Ricardo Correa-Rotter Kidney International

Volume 70, Issue 11, Pages (December 2006)

V.R. Sørensen, P.M. Hansen, J. Heaf, B. Feldt-Rasmussen

The initiation and progression of sickle cell nephropathy

Volume 69, Issue 11, Pages (June 2006)

Volume 71, Issue 7, Pages (April 2007)

Volume 69, Issue 7, Pages (April 2006)

Volume 73, Issue 3, Pages (February 2008)

Volume 62, Issue 3, Pages (September 2002)

Volume 71, Issue 11, Pages (June 2007)

Current status of maintenance hemodialysis in Beijing, China

Organ transplantation goes to the movies

Volume 72, Issue 2, Pages (July 2007)

Diagnosing Alport syndrome using electron microscopy of the skin

Volume 80, Issue 10, Pages (November 2011)

Volume 56, Pages S238-S241 (July 1999)

Is it the low-protein diet or simply the salt restriction?

Volume 70, Issue 3, Pages (August 2006)

Volume 70, Issue 3, Pages (August 2006)

A 39-year-old pregnant woman with polyuria and hypomagnesemia

Advisory about gadolinium calls for caution in the treatment of uremic patients with lanthanum carbonate S. Aime, C. Canavese, P. Stratta Kidney International

Amylin deposition in the kidney of patients with diabetic nephropathy

Volume 69, Issue 3, Pages (February 2006)

Volume 70, Issue 5, Pages (September 2006)

T cells and T-cell receptors in acute renal failure

Volume 70, Issue 10, Pages (November 2006)

The International Pediatric Peritonitis Registry: Starting to walk

Therapy with lamivudine and steroids in a patient with acute hepatitis B and rapidly progressive glomerulonephritis V. Di Marco, S. De Lisi, M. Li Vecchi,

Volume 56, Issue 2, Pages (August 1999)

The tubulointerstitium in progressive diabetic kidney disease: More than an aftermath of glomerular injury? Richard E. Gilbert, Mark E. Cooper Kidney.

Lipoprotein abnormalities in diabetic nephropathy

Volume 57, Pages S44-S48 (April 2000)

Characteristics of sudden death in hemodialysis patients

Alex B. Magil, Kathryn Tinckam Kidney International

Presentation transcript:

Volume 69, Issue 2, Pages 388-392 (January 2006) N2-carboxyethyl-2′-deoxyguanosine, a DNA glycation marker, in kidneys and aortas of diabetic and uremic patients H. Li, S. Nakamura, S. Miyazaki, T. Morita, M. Suzuki, M. Pischetsrieder, T. Niwa Kidney International Volume 69, Issue 2, Pages 388-392 (January 2006) DOI: 10.1038/sj.ki.5000064 Copyright © 2006 International Society of Nephrology Terms and Conditions

Figure 1 Nonenzymatic formation of CEdG by reaction of D-glucose with 2′-deoxyguanosine. Kidney International 2006 69, 388-392DOI: (10.1038/sj.ki.5000064) Copyright © 2006 International Society of Nephrology Terms and Conditions

Figure 2 Immunostaining of CEdG in the kidneys. Diabetic nephropathy: (a, b) glomerulus in a 66-year-old man with serum creatinine 5.5 mg/dl (original magnifications: a, × 100; b, × 250); (c, d) tubules in a 53-year-old man with serum creatinine 2.1 mg/dl (original magnifications: c, × 100; d, × 250). Control: (e, f) glomerulus in a 68-year-old nonkidney disease man with serum creatinine of 0.5 mg/dl (original magnifications: e, × 100; f, × 250); (g, h) tubules in a 43-year-old nonkidney disease man with serum creatinine 0.3 mg/dl (original magnifications: g, × 100; h, × 250). Kidney International 2006 69, 388-392DOI: (10.1038/sj.ki.5000064) Copyright © 2006 International Society of Nephrology Terms and Conditions

Figure 3 Number of CEdG-positive cells in the glomeruli of patients with nondiabetic nonkidney disease (control) and diabetic nephropathy (DN). Data are expressed as mean±s.e. (n=10). Kidney International 2006 69, 388-392DOI: (10.1038/sj.ki.5000064) Copyright © 2006 International Society of Nephrology Terms and Conditions

Figure 4 Immunostaining of CEdG, CD-68, α-SMA, and CD-31 in the aortic walls. (a–d) Diabetic hemodialysis (a 50-year-old man diagnosed with diabetic mellitus 18 years ago and treated on hemodialysis for 4 years); immunostaining with antibodies against (a) CEdG, (b) CD-68, (c) α-SMA, and (d) CD-31 (original magnification × 100). (e–h) Control (a 71-year-old nondiabetic nonhemodialysis woman); immunostaining with antibodies against (e) CEdG, (f) CD-68, (g) α-SMA, and (h) CD-31 (original magnification × 100). Kidney International 2006 69, 388-392DOI: (10.1038/sj.ki.5000064) Copyright © 2006 International Society of Nephrology Terms and Conditions

Figure 5 Number of CEdG-positive cells in aortic walls of patients with nondiabetic nonhemodialysis (control), diabetes mellitus (DM), hemodialysis (HD), and diabetic hemodialysis (DM+HD). Data are expressed as mean±s.e. (n=5). Kidney International 2006 69, 388-392DOI: (10.1038/sj.ki.5000064) Copyright © 2006 International Society of Nephrology Terms and Conditions