MHC Class I Expression in Murine Skin: Developmentally Controlled and Strikingly Restricted Intraepithelial Expression During Hair Follicle Morphogenesis.

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MHC Class I Expression in Murine Skin: Developmentally Controlled and Strikingly Restricted Intraepithelial Expression During Hair Follicle Morphogenesis and Cycling, and Response to Cytokine Treatment In Vivo René Rückert, Udo Hofmann, Carina van der Veen, Ralf Paus Journal of Investigative Dermatology Volume 111, Issue 1, Pages 25-30 (July 1998) DOI: 10.1046/j.1523-1747.1998.00228.x Copyright © 1998 The Society for Investigative Dermatology, Inc Terms and Conditions

Figure 1 Expression of classical and non-classical MHC class I molecules in the murine HF during neonatal development, and induction of MHC-expression in anagen HF after cytokine treatment. Scale bars: (a, c, e–o) 50 μm, (b, d) 100 μm. DP, dermal papilla; HS, hair shaft; C, club hair; SG, sebaceous gland; IRS, inner root sheath; ORS, outer root sheath. (a) Weak H2b staining in the dermis/subcutis/DP of neonatal mice 1 day p.p. (stage 4); (b) increasing H2b staining in the dermis/subcutis, endothelial cells, and distal (upper) ORS of the HF of neonatal mice 5 d p.p. (stage 7); (c) H2b expression in the distal follicle epithelium and the SG on day 19 p.p. (catagen VIII); (d) Qa-2 expression in the DP on day 3 p.p. (stage 6); (e) Qa-2 expression in the distal follicle KC on day 15 p.p. (stage 8); (f) Qa-1 staining in the distal follicular epithelium on day 12 p.p. (stage 8); (g) Qa-1 expression on all follicle KC on day 21 p.p. (telogen); (h) strong upregulation of H2b expression in the anagen bulb KC 24 h after IFN-γ treatment; (i) upregulation of H2b expression in the proximal (lower) anagen hair bulb 6 h after intradermal IFN-γ injection; (j) H2b negativity in anagen hair bulb KC of control mice; (k) weak constitutive expression of TAP-1 in controls in the DP and the ORS; (l) enhanced TAP-1 expression in the proximal hair bulb 24 h after IFN-γ injection; (m) failure of IL-1β to upregulate MHC Ia expression in HF KC; (n) H2b expression 24 h after injection of IL-1β, TNF-α, and IFN-γ; (o) Qa-1 upregulation in proximal follicle KC 24 h after IFN-γ injection. Arrows and arrowheads, see Results. Journal of Investigative Dermatology 1998 111, 25-30DOI: (10.1046/j.1523-1747.1998.00228.x) Copyright © 1998 The Society for Investigative Dermatology, Inc Terms and Conditions