Volume 54, Pages S189-S191 (September 1998)

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Volume 54, Pages S189-S191 (September 1998) Different activation of mitogen-activated protein kinases in experimental proliferative glomerulonephritis Dirk Bokemeyer, Kelly E. Guglielmi, Ann McGinty, Andrey Sorokin, Elias A. Lianos, Michael J. Dunn Kidney International Volume 54, Pages S189-S191 (September 1998) DOI: 10.1046/j.1523-1755.1998.06743.x Copyright © 1998 International Society of Nephrology Terms and Conditions

Figure 1 Activation of extracellular signal-regulated kinase (ERK) in crescentic glomerulonephritis (GN). Upper panel: Western blot analysis shows ERK2 [p42 mitogen-activated protein (MAP) kinase] in whole cortical tissue lysates. At each time point, one control and one experimental animal were studied. Rats were sacrificed at the indicated times following the second injection of anti-glomerular basement membrane (GBM) serum. Activation of ERK is identifiable by an increase of phosphorylated protein forms, detected by bands with delayed mobility (indicated by stars), compared with the unshifted unphosphorylated ERK forms. Lower panels: ERK activity assayed by the ability of immunoprecipitated ERK to phosphorylate myelin basic protein (MBP). Kidney International 1998 54, S189-S191DOI: (10.1046/j.1523-1755.1998.06743.x) Copyright © 1998 International Society of Nephrology Terms and Conditions

Figure 2 Western blot analysis of MAP kinase/ERK kinase (MEK) protein expression in cortical and glomerular lysates. Kidney International 1998 54, S189-S191DOI: (10.1046/j.1523-1755.1998.06743.x) Copyright © 1998 International Society of Nephrology Terms and Conditions

Figure 3 Activation of p38 mitogen-activated protein (MAP) kinase in crescentic glomerulonephritis (GN). At each time point, one control and two experimental animal were studied. Whole lysates of isolated glomeruli were analyzed by Western blot analysis employing an antiserum against the phosphorylated and activated form of p38 MAP kinase. Kidney International 1998 54, S189-S191DOI: (10.1046/j.1523-1755.1998.06743.x) Copyright © 1998 International Society of Nephrology Terms and Conditions