MRI-based extended ordered values more efficiently differentiate cartilage loss in knees with and without joint space narrowing than region-specific approaches.

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Presentation transcript:

MRI-based extended ordered values more efficiently differentiate cartilage loss in knees with and without joint space narrowing than region-specific approaches using MRI or radiography – data from the OA initiative W. Wirth, R. Buck, M. Nevitt, M.P.H. Le Graverand, O. Benichou, D. Dreher, R.Y. Davies, J.H. Lee, K. Picha, A. Gimona, S. Maschek, M. Hudelmaier, F. Eckstein Osteoarthritis and Cartilage Volume 19, Issue 6, Pages 689-699 (June 2011) DOI: 10.1016/j.joca.2011.02.011 Copyright © 2011 Osteoarthritis Research Society International Terms and Conditions

Fig. 1 Double oblique coronal fast low angle shot (FLASH) MR image with water excitation showing the regions of interest analyzed: MFTC (=MT+cMF), LFTC (=LT+cLF). The top part of the figures shows a reconstruction of the weight-bearing parts of the femoral condyles (cMF and cLF) and the lower part a reconstruction of the tibiae (MT and LT). (c|e|i|a|p=central|external|internal|anterior|posterior subregion of MT or LT. c|e|i=central|external|internal subregion of the central part of cMF or cLF). Osteoarthritis and Cartilage 2011 19, 689-699DOI: (10.1016/j.joca.2011.02.011) Copyright © 2011 Osteoarthritis Research Society International Terms and Conditions

Fig. 2 Graph showing the OVs approach: (A) The top spread sheet shows the results (change in cartilage thickness [ThCtAB] in μm) in the femorotibial subregions (see Fig. 1) of four example OAI subjects. (B) The rates of change are ranked according to their magnitude in the middle spread sheet. (C) The magnitudes of the changes (in μm) are then attributed to the orders in the bottom spread sheet. The subregion with the most negative change (decrease in ThCtAB) in each subject is assigned to order one, the subregion showing the second most negative change assigned to order two, and the subregion showing the smallest negative or the greatest positive change (increase in ThCtAB) assigned to order 16. Note that differently located subregions contribute to order one in the four subjects shown. Osteoarthritis and Cartilage 2011 19, 689-699DOI: (10.1016/j.joca.2011.02.011) Copyright © 2011 Osteoarthritis Research Society International Terms and Conditions

Fig. 3 Graphs showing the distribution of P-values obtained from (A) the bootstrapping method and from (B) the randomization of changes in JSN knees. The distribution is shown for the entire MFTC and LFTC, the anterior subregion of the medial tibia (aMT), the mOV1, and the eOV1, eOV16. Osteoarthritis and Cartilage 2011 19, 689-699DOI: (10.1016/j.joca.2011.02.011) Copyright © 2011 Osteoarthritis Research Society International Terms and Conditions