Thomas B. Casale, MDa, I. Leonard Bernstein, MDb, William W

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Presentation transcript:

Use of an anti-IgE humanized monoclonal antibody in ragweed-induced allergic rhinitis Thomas B. Casale, MDa, I.Leonard Bernstein, MDb, William W. Busse, MDc, Craig F. LaForce, MDd, David G. Tinkelman, MDe, Randall R. Stoltz, MDf, Robert J. Dockhorn, MDg, James Reimann, PhDh, John Q. Su, PhDh, Robert B. Fick, MDh, Daniel C. Adelman, MDh Journal of Allergy and Clinical Immunology Volume 100, Issue 1, Pages 110-121 (July 1997) DOI: 10.1016/S0091-6749(97)70202-1 Copyright © 1997 Mosby, Inc. Terms and Conditions

Fig. 1 Geometric means of total rhuMAb-E25 by treatment group. Times are 5 minutes before dose; total rhuMAb-E25 has lower limit of quantification of 16 ng/ml, indicated by the faint dotted line. Journal of Allergy and Clinical Immunology 1997 100, 110-121DOI: (10.1016/S0091-6749(97)70202-1) Copyright © 1997 Mosby, Inc. Terms and Conditions

Fig. 2 Geometric means of free serum IgE by treatment group. Times are 5 minutes before dose; free IgE has limits of quantification of 10 ng/ml and 165 ng/ml. Journal of Allergy and Clinical Immunology 1997 100, 110-121DOI: (10.1016/S0091-6749(97)70202-1) Copyright © 1997 Mosby, Inc. Terms and Conditions

Fig. 3 Geometric means of serum total IgE (A) and ragweed-specific total IgE (B) by treatment group. Times are 5 minutes before dose. Journal of Allergy and Clinical Immunology 1997 100, 110-121DOI: (10.1016/S0091-6749(97)70202-1) Copyright © 1997 Mosby, Inc. Terms and Conditions

Fig. 3 Geometric means of serum total IgE (A) and ragweed-specific total IgE (B) by treatment group. Times are 5 minutes before dose. Journal of Allergy and Clinical Immunology 1997 100, 110-121DOI: (10.1016/S0091-6749(97)70202-1) Copyright © 1997 Mosby, Inc. Terms and Conditions

Fig. 4 A, Steady-state (SS) free IgE against steady-state total E25/total IgE ratio in treated patients. Steady-state concentrations are geometric means of predose values over days 42, 56, 70, and 84. B, Steady-state free IgE against dose/baseline IgE in dosed patients. Steady-state free IgE is geometric mean of predose values over days 42, 56, 70, and 84. Journal of Allergy and Clinical Immunology 1997 100, 110-121DOI: (10.1016/S0091-6749(97)70202-1) Copyright © 1997 Mosby, Inc. Terms and Conditions

Fig. 4 A, Steady-state (SS) free IgE against steady-state total E25/total IgE ratio in treated patients. Steady-state concentrations are geometric means of predose values over days 42, 56, 70, and 84. B, Steady-state free IgE against dose/baseline IgE in dosed patients. Steady-state free IgE is geometric mean of predose values over days 42, 56, 70, and 84. Journal of Allergy and Clinical Immunology 1997 100, 110-121DOI: (10.1016/S0091-6749(97)70202-1) Copyright © 1997 Mosby, Inc. Terms and Conditions

Fig. 5 Mean daily eye and nose symptom scores by study days. Journal of Allergy and Clinical Immunology 1997 100, 110-121DOI: (10.1016/S0091-6749(97)70202-1) Copyright © 1997 Mosby, Inc. Terms and Conditions

Fig. 6 Mean (± SEM) number of days rescue medication was used by treatment group. Plac., Placebo. Journal of Allergy and Clinical Immunology 1997 100, 110-121DOI: (10.1016/S0091-6749(97)70202-1) Copyright © 1997 Mosby, Inc. Terms and Conditions

Fig. 7 Weekly total symptom score by baseline ragweed-specific total IgE (all treatment groups combined). Journal of Allergy and Clinical Immunology 1997 100, 110-121DOI: (10.1016/S0091-6749(97)70202-1) Copyright © 1997 Mosby, Inc. Terms and Conditions

Fig. 8 Weekly total symptom score by free IgE level (all treatment groups combined). Free IgE is geometric mean of predose values on days 14, 28, 42, 56, and 70. Journal of Allergy and Clinical Immunology 1997 100, 110-121DOI: (10.1016/S0091-6749(97)70202-1) Copyright © 1997 Mosby, Inc. Terms and Conditions