Polarity of α-galactosidase A uptake by renal tubule cells

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Presentation transcript:

Polarity of α-galactosidase A uptake by renal tubule cells Aaron S. Stern, Mary E. Klotman, Yiannis A. Ioannou, Christopher R. Burrow, Patricia D. Wilson, Paul E. Klotman, Michael S. Lipkowitz Kidney International Volume 61, Issue 1, Pages S52-S55 (January 2002) DOI: 10.1046/j.1523-1755.2002.0610s1052.x Copyright © 2002 International Society of Nephrology Terms and Conditions

Figure 1 AGA uptake from either the luminal (open bar) or basolateral (solid bar) side of the epithelial cells plated on Transwell filters. Uptake in proximal tubule cells (NHPST), thick ascending limb cells (NHTAL), and cortical collecting duct cells (NHCT) was always greater from the basolateral cell surface. Kidney International 2002 61, S52-S55DOI: (10.1046/j.1523-1755.2002.0610s1052.x) Copyright © 2002 International Society of Nephrology Terms and Conditions

Figure 2 Inhibition by M6-P of AGA uptake from the basolateral surface of NHCT cells. Control, solid bar; M6-P, open bar. Kidney International 2002 61, S52-S55DOI: (10.1046/j.1523-1755.2002.0610s1052.x) Copyright © 2002 International Society of Nephrology Terms and Conditions

Figure 3 A Lineweaver plot of AGA uptake from the luminal (solid circles) or basolateral (open circles) surfaces of NHCT cells. The calculated x intercepts of the linear regression lines for the data represent −1/Km for AGA uptake. Kidney International 2002 61, S52-S55DOI: (10.1046/j.1523-1755.2002.0610s1052.x) Copyright © 2002 International Society of Nephrology Terms and Conditions