Sialyl LewisX oligosaccharide preserves cardiopulmonary and endothelial function after hypothermic circulatory arrest in lambs Marc L. Schermerhorn,

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Presentation transcript:

Sialyl LewisX oligosaccharide preserves cardiopulmonary and endothelial function after hypothermic circulatory arrest in lambs Marc L. Schermerhorn, MDa, Motohisa Tofukuji, MD, PhDd, Philip R. Khoury, MSc, Laurie Phillips, PhDe, Paul R. Hickey, MDb, Frank W. Sellke, MDd, John E. Mayer, MDa, David P. Nelson, MD, PhDc The Journal of Thoracic and Cardiovascular Surgery Volume 120, Issue 2, Pages 230-237 (August 2000) DOI: 10.1067/mtc.2000.107123 Copyright © 2000 American Association for Thoracic Surgery Terms and Conditions

Fig. 1 Myocardial contractile function in control and CY1503-treated animals during reperfusion. The upper panel demonstrates that PRSWI (a load-independent measure of contractile function) is greater in Cy1503-treated animals throughout reperfusion (P =.001, overall difference between groups determined by repeated-measures analysis of variance). The lower panels show that +dP/dt and –dP/dt (load-dependent measures of myocardial function) are greater in CY1503-treated animals throughout reperfusion (P =.04 and.01, respectively). Results are expressed as the percentage recovery of baseline value (mean ± SD). The Journal of Thoracic and Cardiovascular Surgery 2000 120, 230-237DOI: (10.1067/mtc.2000.107123) Copyright © 2000 American Association for Thoracic Surgery Terms and Conditions

Fig. 2 Pulmonary function in control and CY1503-treated animals during reperfusion. Although pulmonary mechanics are not markedly impaired after CBP-DHCA, dynamic lung compliance and expiratory airway resistance are slightly better in CY1503-treated animals throughout reperfusion (P =.014 and.037, respectively; overall difference between groups determined by repeated-measures analysis of variance). Results are expressed as the percentage recovery of baseline value (mean ± SD). The Journal of Thoracic and Cardiovascular Surgery 2000 120, 230-237DOI: (10.1067/mtc.2000.107123) Copyright © 2000 American Association for Thoracic Surgery Terms and Conditions

Fig. 3 In vitro dose responses of pulmonary microvessels to the endothelium-dependent and endothelium-independent agonists acetylcholine (A) and sodium nitroprusside (B) in control, CPB-saline, and CPB-CY1503 groups (displayed as log to the base 10 of the specific vasodilator). Vessels were precontracted with U46619, and responses are given as percentage relaxation of U46619-induced vessel contraction. CPB with circulatory arrest resulted in significant pulmonary endothelial dysfunction, which was prevented by CY1503 treatment. Asterisks indicate overall difference in dose response of the control and CPB-CY1503 groups compared with the CPB-saline group, as determined by repeated-measures analysis of variance and the Scheffé test post hoc (P <.01). The Journal of Thoracic and Cardiovascular Surgery 2000 120, 230-237DOI: (10.1067/mtc.2000.107123) Copyright © 2000 American Association for Thoracic Surgery Terms and Conditions

Fig. 4 In vitro dose-responses of coronary microvessels to the endothelium-dependent and endothelium-independent agonists A23187 (A) and sodium nitroprusside (B) in the control, CPB-saline, and CPB-CY1503 groups (displayed as log to the base 10 of the specific vasodilator). Vessels were precontracted with U46619, and responses are given as percentage relaxation of U46619-induced vessel contraction. CPB with circulatory arrest resulted in significant coronary endothelial dysfunction, which was prevented by CY1503 treatment. Asterisks indicate overall difference in dose response of the control and CPB-CY1503 groups compared with the CPB-saline group, as determined by repeated-measures analysis of variance and the Scheffé test post hoc (P <.01). The Journal of Thoracic and Cardiovascular Surgery 2000 120, 230-237DOI: (10.1067/mtc.2000.107123) Copyright © 2000 American Association for Thoracic Surgery Terms and Conditions