Correlations between concentrations of interleukin-12 and interleukin-13 and lymphocyte subsets in the follicular fluid of women with and without polycystic.

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Presentation transcript:

Correlations between concentrations of interleukin-12 and interleukin-13 and lymphocyte subsets in the follicular fluid of women with and without polycystic ovary syndrome Andrea Gallinelli, M.D., Ph.D., Ivan Ciaccio, M.D., Luca Giannella, M.D., Michela Salvatori, M.D., Tiziana Marsella, Ph.D., Annibale Volpe, M.D. Fertility and Sterility Volume 79, Issue 6, Pages 1365-1372 (June 2003) DOI: 10.1016/S0015-0282(03)00344-3

FIGURE 1 Interleukin (IL)-12 and IL-13 levels in follicular fluid (FF). Values are reported as mean ± SD. *P<.05; **P<.01. FF IL-12 levels were significantly lower in patients with polycystic ovarian syndrome (PCOS) than in normally ovulating women (NOW) (mean: 1.47 ± 0.3 pg/mL vs. 2.25 ± 0.7 pg/mL, respectively; P<.05); in contrast, FF IL-13 concentrations were significantly higher in the PCOS than in the NOW group (mean: 32.5 ± 3.7 pg/mL vs. 19.6 ± 2.5 pg/mL, respectively; P<.01). Gallinelli. Cytokines and T-cell activation in PCOS.Fertil Steril 2003. Fertility and Sterility 2003 79, 1365-1372DOI: (10.1016/S0015-0282(03)00344-3)

FIGURE 2 (A) Activated T-lymphocyte levels in follicular fluid (FF). Values are expressed as percent of cell concentration (mean ± SD). ***P<.001. The total number of activated T lymphocytes detected in FF of normally ovulating women (NOW) was significantly higher than that observed in women with polycystic ovarian syndrome (PCOS) (11.5% ± 1.5% vs. 4.8% ± 0.4%; P<0.001). (B) Follicular fluid T-helper and T-suppressor cell levels. Values are expressed as percent of cell concentration. *P<.05. On average, the percentage of FF T-helper lymphocytes was significantly higher in NOW than in in women with PCOS (48.2% ± 5.1% vs. 42.4% ± 4.8%; P<.05, panel A), whereas FF T suppressor lymphocytes were significantly higher in women with PCOS than in NOW (36.2% ± 3.4% vs. 31.1% ± 3%; P<.05, panel B). Gallinelli. Cytokines and T-cell activation in PCOS.Fertil Steril 2003. Fertility and Sterility 2003 79, 1365-1372DOI: (10.1016/S0015-0282(03)00344-3)

FIGURE 3 Correlations between follicular fluid (FF) activated T lymphocyte cells (ATC) amounts and FF interleukin (IL)-12 and IL-13 levels in the normally ovulating women (NOW) (dots) and in patients with PCOS (triangles). Values of the ATC are percent of cell concentration. A positive correlation between FF ATC and IL-12 concentrations (r = 0.63 and r = 0.67 for NOW and PCOS, respectively; P<.01; A and B) and, in contrast, an inverse correlation between FF ATC amounts and IL-13 levels (r = −0.51 and r = −0.48 for NOW and PCOS, respectively; P<.01; C and D). Gallinelli. Cytokines and T-cell activation in PCOS.Fertil Steril 2003. Fertility and Sterility 2003 79, 1365-1372DOI: (10.1016/S0015-0282(03)00344-3)