Does Pain Mediate the Pain Interference with Sleep Problem in Chronic Pain? Findings from Studies for Management of Diabetic Peripheral Neuropathic Pain.

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Does Pain Mediate the Pain Interference with Sleep Problem in Chronic Pain? Findings from Studies for Management of Diabetic Peripheral Neuropathic Pain with Duloxetine David A. Fishbain, MD, Jerry Hall, MD, Adam L. Meyers, MS, Jill Gonzales, BS, Craig Mallinckrodt, PhD Journal of Pain and Symptom Management Volume 36, Issue 6, Pages 639-647 (December 2008) DOI: 10.1016/j.jpainsymman.2007.12.012 Copyright © 2008 Terms and Conditions

Fig. 1 Time course of change in 24-hour average pain severity in pooled patients with DPNP who did not demonstrate somnolence and were not on sedating medications. MMRM=mixed-effects model repeated measures; DPNP=diabetic peripheral neuropathic pain. Journal of Pain and Symptom Management 2008 36, 639-647DOI: (10.1016/j.jpainsymman.2007.12.012) Copyright © 2008 Terms and Conditions

Fig. 2 Time course of change in night pain severity in pooled patients with DPNP who did not demonstrate somnolence and were not on sedating medications. MMRM=mixed-effects model repeated measures; DPNP=diabetic peripheral neuropathic pain. Journal of Pain and Symptom Management 2008 36, 639-647DOI: (10.1016/j.jpainsymman.2007.12.012) Copyright © 2008 Terms and Conditions

Fig. 3 Improvement in interference with sleep as measured by BPI in pooled patients with DPNP who did not demonstrate somnolence and were not on sedating medications. BPI=Brief Pain Inventory; MMRM=mixed-effects model repeated measures; DPNP=diabetic peripheral neuropathic pain. Journal of Pain and Symptom Management 2008 36, 639-647DOI: (10.1016/j.jpainsymman.2007.12.012) Copyright © 2008 Terms and Conditions