Volume 118, Issue 3, Pages (March 2000)

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Volume 118, Issue 3, Pages 565-572 (March 2000) Role of angiotensin II in regulation of basal and sympathetically stimulated vascular tone in early and advanced cirrhosis Ahmed Helmy*, Rajiv Jalan*, David Ernest Newby‡, Peter Clive Hayes*, David John Webb§ Gastroenterology Volume 118, Issue 3, Pages 565-572 (March 2000) DOI: 10.1016/S0016-5085(00)70263-0 Copyright © 2000 American Gastroenterological Association Terms and Conditions

Fig. 1 Schematic diagram of the 2 study protocols 1 week apart. F, Bilateral FBF measurements each for 3 minutes; L, LBNP application each for 3 minutes. NE doses are in picomoles per minute, ANG II doses in picomoles per minute, and losartan doses in micrograms per minute. Gastroenterology 2000 118, 565-572DOI: (10.1016/S0016-5085(00)70263-0) Copyright © 2000 American Gastroenterological Association Terms and Conditions

Fig. 2 Responses in FBF to incremental doses of ANG II (pmol/min) and NE (pmol/min). NS, not significant. Results are mean ±SEM. Gastroenterology 2000 118, 565-572DOI: (10.1016/S0016-5085(00)70263-0) Copyright © 2000 American Gastroenterological Association Terms and Conditions

Fig. 3 Responses in FBF to losartan infusions in the 3 studied groups. Results are mean ±SEM. *P < 0.01 by 3-way ANOVA; refractory ascites vs. preascitic cirrhosis and controls. Gastroenterology 2000 118, 565-572DOI: (10.1016/S0016-5085(00)70263-0) Copyright © 2000 American Gastroenterological Association Terms and Conditions

Fig. 4 Responses in FBF to LBNP application in the 3 studied groups during saline (2), 30 μg/min losartan (▩), and 90 μg/min losartan (■) infusions. Results are mean ±SEM. *P < 0.01 by 3-way ANOVA; refractory ascites vs. preascitic cirrhosis and controls. Gastroenterology 2000 118, 565-572DOI: (10.1016/S0016-5085(00)70263-0) Copyright © 2000 American Gastroenterological Association Terms and Conditions