Fibrosis and renal aging

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Fibrosis and renal aging Hai-Chun Yang, Agnes B. Fogo Kidney International Supplements Volume 4, Issue 1, Pages 75-78 (November 2014) DOI: 10.1038/kisup.2014.14 Copyright © 2014 International Society of Nephrology Terms and Conditions

Figure 1 Young bone marrow reduces renal injury in aging. The bone marrow from young mice or old mice was transplanted into aged mice. Six months later, there was more interstitial fibrosis and glomerular mesangial expansion in old-to-old (O2O) compared with young-to-old (Y2O) bone marrow transplant mice ((a) periodic acid–Schiff staining, × 200). Young bone marrow resulted in significantly less glomerular collagen IV deposition than old bone marrow ((b) × 400). Klotho, the antiaging protein, is mainly expressed in distal tubules. Its level was preserved in young bone marrow–transplanted mice, and was decreased in old bone marrow–transplanted mice (c). Kidney International Supplements 2014 4, 75-78DOI: (10.1038/kisup.2014.14) Copyright © 2014 International Society of Nephrology Terms and Conditions