Next-generation sequencing of idiopathic multicentric and unicentric Castleman disease and follicular dendritic cell sarcomas by Alexandra Nagy, Aparna.

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Next-generation sequencing of idiopathic multicentric and unicentric Castleman disease and follicular dendritic cell sarcomas by Alexandra Nagy, Aparna Bhaduri, Nahid Shahmarvand, Jahanbanoo Shahryari, James L. Zehnder, Roger A. Warnke, Tariq Mughal, Siraj Ali, and Robert S. Ohgami BloodAdv Volume 2(5):481-491 March 13, 2018 © 2018 by The American Society of Hematology

Alexandra Nagy et al. Blood Adv 2018;2:481-491 © 2018 by The American Society of Hematology

Somatic gene mutations and CNVs in cases of UCD and HHV8−/iMCD and FDCS associated with UCD-HVV. Somatic gene mutations and CNVs in cases of UCD and HHV8−/iMCD and FDCS associated with UCD-HVV. Depicted is an unsupervised hierarchical cluster analysis of genetic alterations in UCD, iMCD, and FDCS associated with UCD-HVV. The top portion depicts somatic mutations in all UCD, iMCD, and FDCS cases (green boxes indicate genes mutated in individual cases); the bottom portion depicts CNVs in all UCD, iMCD, and FDCS cases. CNV gains are in red, whereas CNV losses are in blue. Gray boxes indicate genes without abnormalities. White areas/boxes indicate genes not evaluated by targeted sequencing. iMCD-M, HHV8−/iMCD with mixed histology; iMCD-PC, HHV8−/iMCD with plasma cell histology. Alexandra Nagy et al. Blood Adv 2018;2:481-491 © 2018 by The American Society of Hematology

Morphologic features of cases of UCD and MCD with genetic abnormalities. Morphologic features of cases of UCD and MCD with genetic abnormalities. (A-B) Case 3, HHV8−/iMCD with plasmacytic histology. At low-power magnification, regressed follicles are seen with onion skinning of mantle zones and “twinning” of follicles; increased plasma cells are clearly seen in interfollicular regions with mild vascularity. (C-D) Case 5, UCD-MV. At low-power magnification, regressed follicles are seen with onion skinning of mantle zones along with increased vascularity in interfollicular regions. At high-power magnification, increased plasma cells are clearly seen along with increased vascularity. (E-F) Case 14, UCD-HVV. At low-power magnification, regressed follicles are seen with prominent onion skinning of mantle zones and “twinning” of follicles. At high-power magnification, increased vascularity is present without increased plasma cells. In all panels, images on cases are taken in sequence at ×100 (left) and ×400 (right) magnification; all images are from hematoxylin and eosin–stained slides. Alexandra Nagy et al. Blood Adv 2018;2:481-491 © 2018 by The American Society of Hematology