Role of Endothelin-1 Receptor Antagonists in Vasoconstriction Mediated by Endothelin and Other Vasoconstrictors in Human Internal Mammary Artery Guo-Wei.

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Presentation transcript:

Role of Endothelin-1 Receptor Antagonists in Vasoconstriction Mediated by Endothelin and Other Vasoconstrictors in Human Internal Mammary Artery Guo-Wei He, MD, DSc, Ming-Hui Liu, MD, Qin Yang, MD, PhD, Anthony Furnary, MD, Anthony P.C. Yim, MD The Annals of Thoracic Surgery Volume 84, Issue 5, Pages 1522-1527 (November 2007) DOI: 10.1016/j.athoracsur.2007.05.064 Copyright © 2007 The Society of Thoracic Surgeons Terms and Conditions

Fig 1 Mean concentration (−log M)-relaxation curves (n = 8 from eight patients in each group) for BQ-123 (A) or BQ-788 (B) in isolated human internal mammary artery rings precontracted by ET-1 (closed triangle; 10 nM), angiotensin II (open triangle; 3 nM), thromboxane A2 mimetic U46619 (closed circle; 10 nM), and potassium chloride (open circle; 25 mM). The relaxation is expressed as percent reversal of the vasoconstrictor-induced contraction. Values are expressed as mean ± standard error of the mean. (*p ≤ 0.05 vs other groups, one-way analysis of variance.) The Annals of Thoracic Surgery 2007 84, 1522-1527DOI: (10.1016/j.athoracsur.2007.05.064) Copyright © 2007 The Society of Thoracic Surgeons Terms and Conditions

Fig 2 Mean concentration (−log M)-contraction curves (n = 8 from eight patients in each group) to ET-1 (A), AII (B), U46619 (C), and potassium chloride (KCl) (D) in isolated human internal mammary artery incubated with BQ-123 (open triangle; 1 μm), BQ-788 (closed circle; 1 μm), BQ-123 (1 μm) + BQ-788 (1 μm) (open circle), or vehicle as control (closed triangle). The contraction is expressed as the percentage of the contraction force induced by KCl (100 mM) (see “Method”). Values are expressed as mean ± standard error of the mean. (*p ≤ 0.01 vs control group, two-way analysis of variance.) The Annals of Thoracic Surgery 2007 84, 1522-1527DOI: (10.1016/j.athoracsur.2007.05.064) Copyright © 2007 The Society of Thoracic Surgeons Terms and Conditions