Hiroyuki Tateno, Ph. D. , Hidenori Akutsu, M. D

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Inability of mature oocytes to create functional haploid genomes from somatic cell nuclei Hiroyuki Tateno, Ph.D., Hidenori Akutsu, M.D., Yujiroh Kamiguchi, Ph.D., Keith E. Latham, Ph.D., Ryuzo Yanagimachi, Ph.D. Fertility and Sterility Volume 79, Issue 1, Pages 216-218 (January 2003) DOI: 10.1016/S0015-0282(02)04537-5

FIGURE 1 (A), Variation in number of mouse cumulus chromosomes remaining in the oocyte after the emission of a pseudo polar body. N is the total number of oocytes examined. (B), Fluorescence microscopy of an oocyte incubated for 2–3 hours after enucleation, followed by injection of a mouse cumulus cell nucleus. (a: Immunocytochemical staining of spindle; b: 4′,6-diamidino-2-phenylindole [DAPI] staining of chromosomes. Spindle microtubules are aberrantly assembled, and chromosomes are distributed in a disorderly fashion. Tateno. Aneuploidy in reconstructed oocytes. Fertil Steril 2003. Fertility and Sterility 2003 79, 216-218DOI: (10.1016/S0015-0282(02)04537-5)