Sixteen-Year Longitudinal Changes in Serum Prostate-Specific Antigen Levels: The Olmsted County Study  Steven J. Jacobsen, MD, PhD, Debra J. Jacobson, MS, Michaela E. McGree, BS, Jennifer L. St. Sauver, PhD, George G. Klee, MD, PhD, Cynthia J. Girman, DrPH, Michael M. Lieber, MD  Mayo Clinic Proceedings  Volume 87, Issue 1, Pages 34-40 (January 2012) DOI: 10.1016/j.mayocp.2011.09.002 Copyright © 2012 Mayo Foundation for Medical Education and Research Terms and Conditions

FIGURE 1 Box plots representing the observed distributions of relative (percentage) annual change in serum prostate-specific antigen levels, by interval between assessments in the Olmsted County Study of Urinary Symptoms and Health Status Among Men, 1990-2007. The limits of the boxes represent the 25th and 75th percentiles, and the line within the box represents the median. The limits of the whiskers represent the 5th and 95th percentiles. Mayo Clinic Proceedings 2012 87, 34-40DOI: (10.1016/j.mayocp.2011.09.002) Copyright © 2012 Mayo Foundation for Medical Education and Research Terms and Conditions

FIGURE 2 Nomogram representing the distributions of serum PSA levels 2 years after initial assessment as a function of baseline serum PSA level. The x-axis represents the baseline serum PSA level, and the y-axis represents the follow-up serum PSA level. The top of the blue area represents the 75th percentile of the observed change. The top of the gold area represents the 95th percentile of the observed change. PSA = prostate-specific antigen. Mayo Clinic Proceedings 2012 87, 34-40DOI: (10.1016/j.mayocp.2011.09.002) Copyright © 2012 Mayo Foundation for Medical Education and Research Terms and Conditions