Genomewide Search and Genetic Localization of a Second Gene Associated with Autosomal Dominant Branchio-Oto-Renal Syndrome: Clinical and Genetic Implications

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Genomewide Search and Genetic Localization of a Second Gene Associated with Autosomal Dominant Branchio-Oto-Renal Syndrome: Clinical and Genetic Implications Shrawan Kumar, Karen Deffenbacher, Henri A.M. Marres, Cor W.R.J. Cremers, William J. Kimberling The American Journal of Human Genetics Volume 66, Issue 5, Pages 1715-1720 (May 2000) DOI: 10.1086/302890 Copyright © 2000 The American Society of Human Genetics Terms and Conditions

Figure 1 Genotypic data for 1q markers, listed in centromere-to-telomere order, for the kindred with BO. Haplotype results that are associated with affected status are indicated by a red bar. The genotypes shown in parentheses are inferred from their children. The American Journal of Human Genetics 2000 66, 1715-1720DOI: (10.1086/302890) Copyright © 2000 The American Society of Human Genetics Terms and Conditions

Figure 2 Ideogram of chromosome 1. The genetic distance between markers is presented, and the approximate location of the BO gene is indicated by a vertical bar. The American Journal of Human Genetics 2000 66, 1715-1720DOI: (10.1086/302890) Copyright © 2000 The American Society of Human Genetics Terms and Conditions

Figure 3 Multipoint analysis. Multipoint LOD scores observed between the BO phenotype and markers on the chromosome 1q31 region are presented on the X-axis, and the positions of markers loci are located on the Y-axis. The order of markers and the genetic θ used in the analyses are as in figure 1. The American Journal of Human Genetics 2000 66, 1715-1720DOI: (10.1086/302890) Copyright © 2000 The American Society of Human Genetics Terms and Conditions