Inhibitory effect of milrinone on cytokine production after cardiopulmonary bypass Nobuhiko Hayashida, MD, PhD, Hiroshi Tomoeda, MD, Takeshi Oda, MD,

Slides:

Advertisements

Similar presentations

Stress-Dose Corticosteroid Versus Placebo in Neonatal Cardiac Operations: A Randomized Controlled Trial Pertti K. Suominen, MD, PhD, Juho Keski-Nisula,

Advertisements

Cardiac surgery with cardiopulmonary bypass in patients with type II heparin-induced thrombocytopenia Abdellah Aouifi, MD, Pascale Blanc, MD, Vincent.

Cytokine release and neutrophil activation are not prevented by heparin-coated circuits and aprotinin administration Jean-Olivier Defraigne, MD, PhD,

Proinflammatory and antiinflammatory cytokines after cardiac operation: different cellular sources at different times Axel Franke, MD, Wolfgang Lante,

A Closed Perfusion System With Heparin Coating and Centrifugal Pump Improves Cardiopulmonary Bypass Biocompatibility in Elderly Patients Lena Lindholm,

Amit Mathur, MD, Maher Baz, MD, E

Reduction of heparin dose is not beneficial to platelet function

P. W. Boonstra, MD, PhD, Y. J. Gu, MD, PhD, C. Akkerman, BSc, J

James L Zellner, MD, Scott B Kribbs, BS, B

Bashir M Matata, PhD, Andrzej W Sosnowski, MD, Manuel Galiñanes

Effect of perfusion flow rate on tissue oxygenation in newborn piglets during cardiopulmonary bypass Gregory Schears, MD, Steven E Schultz, MD, Jennifer.

Aprotinin and Dipyridamole for the Safe Reduction of Postoperative Blood Loss Gideon Cohen, Joan Ivanov, Richard D Weisel, Vivek Rao, Molly K Mohabeer,

Penehyclidine hydrochloride preserves the intestinal barrier function in patients undergoing cardiopulmonary bypass Ying-jie Sun, PhD, Dan-dan Song,

Sivelestat Attenuates Lung Injury in Surgery for Congenital Heart Disease With Pulmonary Hypertension Norikazu Nomura, MD, PhD, Miki Asano, MD, PhD,

Effects of Depletion of Leukocytes and Platelets on Cardiac Dysfunction After Cardiopulmonary Bypass Yukio Chiba, Kouichi Morioka, Ryusuke Muraoka, Akio.

Coagulofibrinolysis during heparin-coated cardiopulmonary bypass with reduced heparinization Hiroshi Kumano, MD, PhD, Shigefumi Suehiro, MD, PhD, Koji.

Simvastatin Increases Neutrophil Apoptosis and Reduces Inflammatory Reaction After Coronary Surgery Massimo Chello, MD, Amedeo Anselmi, MD, Cristiano.

How safe is the port access technique in minimally invasive coronary artery bypass grafting? Selami Dogan, MD, Kai Graubitz, MD, Tayfun Aybek, MD, Mohammad.

Susanne Lison, MD, Michael Spannagl, MD, PhD, Wulf Dietrich, MD, PhD

Oxidative Stress and Atrial Fibrillation After Cardiac Surgery: A Case-Control Study Basel Ramlawi, MD, MMSc, Hasan Otu, PhD, Shigetoshi Mieno, MD, Munir.

Hedi H Schreurs, Marianne J Wijers, Y

An Analysis of Oxygen Consumption and Oxygen Delivery in Euthermic Infants After Cardiopulmonary Bypass With Modified Ultrafiltration Jia Li, MD, PhD,

Effect of Heparin Loading During Congenital Heart Operation on Thrombin Generation and Blood Loss Sophronia O Turner-Gomes, MB, ChB, Evan P Nitschmann,

Human cytokine responses to coronary artery bypass grafting with and without cardiopulmonary bypass Martin Strüber, MD, Jochen T Cremer, MD, Bernhard.

Comparison of bovine and porcine heparin in heparin antibody formation after cardiac surgery John L Francis, PhD, George J Palmer, MD, Rebecca Moroose,

Relationship Between Antiinflammatory Cytokine Interleukin-10 and Lactate Concentrations in Neonates Undergoing the Arterial Switch Operation Kyrylo.

Comparative effects of propofol versus fentanyl on cerebral oxygenation state during normothermic cardiopulmonary bypass and postoperative cognitive dysfunction

Stress-Dose Corticosteroid Versus Placebo in Neonatal Cardiac Operations: A Randomized Controlled Trial Pertti K. Suominen, MD, PhD, Juho Keski-Nisula,

Robert C King, MD, Victor E Laubach, PhD, R

Clinical performance and biocompatibility of poly(2-methoxyethylacrylate)—coated extracorporeal circuits Serdar Gunaydin, MD, Bora Farsak, MD, Mustafa.

Cardiac surgery with cardiopulmonary bypass in patients with type II heparin-induced thrombocytopenia Abdellah Aouifi, MD, Pascale Blanc, MD, Vincent.

Anne H Kuitunen, MD, Lasse J Heikkilä, MD, Markku T Salmenperä, MD

Coronary surgery without cardiotomy suction and autotransfusion reduces the postoperative systemic inflammatory response Martin Westerberg, MD, Anders.

Nitecapone as an additive to crystalloid cardioplegia in patients who had coronary artery bypass grafting Antti E Vento, MD, Juha Aittomäki, MD, Kalervo.

Infant cardiopulmonary bypass: a procoagulant state

Cassandra Joffs, MD, Himali R. Gunasinghe, BS, Marlina M

Editorial Board, January 2010

Bradford B. Smith, MD, Matthew A

Anticoagulation with bivalirudin during cardiopulmonary bypass in cardiac surgery Julio C Vasquez, MD, Anna Vichiendilokkul, PharmD, Syed Mahmood, MD,

Individualized heparin and protamine management in infants and children undergoing cardiac operations Massimiliano Codispoti, MD, Christopher A Ludlam,

Drew-Anderson technique attenuates systemic inflammatory response syndrome and improves respiratory function after coronary artery bypass grafting Josef.

No benefit of reduced heparinization in thoracic aortic operation with heparin-coated bypass circuits Christian Olsson, MD, Agneta Siegbahn, MD, PhD,

Beneficial effects of ischemic preconditioning on right ventricular function after coronary artery bypass grafting Zhong-Kai Wu, MD, Matti R Tarkka,

Ronald A. Bronicki, MD, Carl L. Backer, MD, Harris P

Cardiac surgery with deep hypothermic circulatory arrest produces less systemic inflammatory response than low-flow cardiopulmonary bypass in newborns

Inflammatory Mediators in Adults Undergoing Cardiopulmonary Bypass: Comparison of Centrifugal and Roller Pumps Saeed Ashraf, John Butler, Yi Tian, Dahlia.

Sune Damgaard, MD, PhD, Claus H. Nielsen, MD, PhD, Lars W

Effect of modified ultrafiltration on plasma thromboxane B2, leukotriene B4, and endothelin-1 in infants undergoing cardiopulmonary bypass Jeffrey M.

Effect of cardiopulmonary bypass on pulmonary gas exchange: a prospective randomized study Craig M Cox, Raimondo Ascione, MD, Alan M Cohen, Ian M Davies,

Neurocognitive Function and Cerebral Emboli: Randomized Study of On-Pump Versus Off-Pump Coronary Artery Bypass Surgery Reza Motallebzadeh, MRCS, J.

Use of recombinant factor VIIa as a rescue treatment for intractable bleeding following repeat aortic arch repair Greg Stratmann, MD, PhD, Isobel A Russell,

Exacerbation of systemic inflammation and increased cerebral infarct volume with cardiopulmonary bypass after focal cerebral ischemia in the rat H. Mayumi.

Anthony P.C Yim, MD, Song Wan, MD, PhD, Tak Wai Lee, Ahmed A Arifi

Aprotinin Enhances the Endogenous Release of Interleukin-10 After Cardiac Operations Gary E Hill, Robert P Diego, Alfred H Stammers, Suzanne M Huffman,

Comparison of epsilon aminocaproic acid and low-dose aprotinin in cardiopulmonary bypass: efficiency, safety and cost Michael J Ray, PhD, Mark F O’Brien

Tissue oxygenation index is a useful monitor of histologic and neurologic outcome after cardiopulmonary bypass in piglets Ikuo Hagino, MD, Vesa Anttila,

Effect of Nitric Oxide Gas on Platelets During Open Heart Operations

“Transitions” for Cardiothoracic Surgeons Now Listed on the Web:

Comparison of Blood Activation in the Wound, Active Vent, and Cardiopulmonary Bypass Circuit Olivier Fabre, MD, PhD, André Vincentelli, MD, PhD, Delphine.

Induction of Interleukin-19 and Interleukin-22 After Cardiac Surgery With Cardiopulmonary Bypass Chung-Hsi Hsing, MD, Mei-Yi Hsieh, MS, Wei-Yu Chen,

Pulmonary function, postoperative pain, and serum cytokine level after lobectomy: a comparison of VATS and conventional procedure Itaru Nagahiro, MD,

Effects of Methylprednisolone and a Biocompatible Copolymer Circuit on Blood Activation During Cardiopulmonary Bypass Fraser D. Rubens, MD, Howard Nathan,

Reduced Cytokines Release and Myocardial Damage in Coronary Artery Bypass Patients Due to L-Arginine Cardioplegia Supplementation Luisa Colagrande, MD,

Neutrophil CD11b upregulation during cardiopulmonary bypass is associated with postoperative renal injury Christine S Rinder, MD, Manuel Fontes, MD,

Balance of proinflammatory and antiinflammatory cytokines at thoracic cancer operation Darryl M Atwell, MD, Katherine P Grichnik, MD, Mark F Newman, MD,

Karl A. Bocchieri, BS, CCP, S. Jacob Scheinerman, MD, L

Safety of low hematocrits during cardiopulmonary bypass

Y.John Gu, MD, PhD, Piet W. Boonstra, MD, PhD, Willem van Oeveren, PhD

A randomized trial of antithrombin concentrate for treatment of heparin resistance Mathew R Williams, MD, Alyssa B D’Ambra, BA, James R Beck, Talia B.

Myocardial, Inflammatory, and Stress Responses in Off-Pump Coronary Artery Bypass Graft Surgery With Thoracic Epidural Anesthesia Massimo Caputo, MD,

Presentation transcript:

Inhibitory effect of milrinone on cytokine production after cardiopulmonary bypass Nobuhiko Hayashida, MD, PhD, Hiroshi Tomoeda, MD, Takeshi Oda, MD, Eiki Tayama, MD, Shingo Chihara, MD, Takemi Kawara, MD, Shigeaki Aoyagi, MD The Annals of Thoracic Surgery Volume 68, Issue 5, Pages 1661-1667 (November 1999) DOI: 10.1016/S0003-4975(99)00716-X

Fig 1 Cytokine and cyclic adenosine monophosphate (cAMP) levels. Interleukin-1β (IL-1β) levels at the end of cardiopulmonary bypass (CPB) and interleukin-6 (IL-6) levels 1 and 3 hours after cardiopulmonary bypass were significantly lower in the milrinone group than those in the control group. Cyclic adenosine monophosphate levels were significantly greater in the milrinone group than those in the control group 5 minutes after initiation, at the end, and 1 hour after cardiopulmonary bypass. (Control = control group; IL-8 = interleukin-8; Ind = induction of anesthesia; Milrinone = milrinone group; NS = not significant; Off = at the end of cardiopulmonary bypass; On = 5 minutes after initiation of cardiopulmonary bypass.) The Annals of Thoracic Surgery 1999 68, 1661-1667DOI: (10.1016/S0003-4975(99)00716-X)

Fig 2 Relationship between the plasma cyclic adenosine monophosphate (cAMP) and interleukin-6 (IL-6) levels. Plasma cyclic adenosine monophosphate levels at the end of cardiopulmonary bypass correlated inversely (r = −0.56, p < 0.01) with interleukin-6 levels 3 hours after cardiopulmonary bypass. (Control = control group; Milrinone = milrinone group.) The Annals of Thoracic Surgery 1999 68, 1661-1667DOI: (10.1016/S0003-4975(99)00716-X)