Pharmacokinetics and individualized dose adjustment of intravenous busulfan in children with advanced hematologic malignancies undergoing allogeneic stem.

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Presentation transcript:

Pharmacokinetics and individualized dose adjustment of intravenous busulfan in children with advanced hematologic malignancies undergoing allogeneic stem cell transplantation Hai Tran, Demetrios Petropoulos, Laura Worth, Craig A. Mullen, Timothy Madden, Borje Andersson, Mary Choroszy, John Nguyen, Susannah K. Webb, Ka Wah Chan Biology of Blood and Marrow Transplantation Volume 10, Issue 11, Pages 805-812 (November 2004) DOI: 10.1016/j.bbmt.2004.07.010 Copyright © 2004 American Society for Blood and Marrow Transplantation Terms and Conditions

Figure 1 IBVU clearance by age group. Comparison of final clearance between the 2 age groups of individuals younger than 6 years (n = 9; mean, 4.49 mL/min/kg; SD, 0.69 mL/min/kg) and those 6 years or older (n = 9; mean, 3.35 mL/min/kg; SD, 0.67 mL/min/kg). Student t test; P = .0026; df = 16. Biology of Blood and Marrow Transplantation 2004 10, 805-812DOI: (10.1016/j.bbmt.2004.07.010) Copyright © 2004 American Society for Blood and Marrow Transplantation Terms and Conditions