Choosing Wisely? Measuring the Burden of Medications in Older Adults near the End of Life: Nationwide, Longitudinal Cohort Study Lucas Morin, MS, Davide.

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Presentation transcript:

Choosing Wisely? Measuring the Burden of Medications in Older Adults near the End of Life: Nationwide, Longitudinal Cohort Study Lucas Morin, MS, Davide L. Vetrano, MD, Debora Rizzuto, PhD, Amaia Calderón-Larrañaga, PhD, Johan Fastbom, MD, PhD, Kristina Johnell, PhD The American Journal of Medicine Volume 130, Issue 8, Pages 927-936.e9 (August 2017) DOI: 10.1016/j.amjmed.2017.02.028 Copyright © 2017 The Authors Terms and Conditions

Figure (A) Polypharmacy and (B) number of prescription drugs over the course of the last 12 months of life of older people in Sweden, by living arrangement. Proportions and means are standardized for both sex and age, using the total population as reference. All trends statistically significant (P <.01). The American Journal of Medicine 2017 130, 927-936.e9DOI: (10.1016/j.amjmed.2017.02.028) Copyright © 2017 The Authors Terms and Conditions

Supplementary Figure 1 Study population flowchart. The American Journal of Medicine 2017 130, 927-936.e9DOI: (10.1016/j.amjmed.2017.02.028) Copyright © 2017 The Authors Terms and Conditions

Supplementary Figure 2 Design of drug exposure calculation. Tick marks represent the date of drug dispensing (“start date”). Horizontal lines represent the estimated duration of drug exposure. Arrows represent the end of drug exposure (“end date”). The American Journal of Medicine 2017 130, 927-936.e9DOI: (10.1016/j.amjmed.2017.02.028) Copyright © 2017 The Authors Terms and Conditions

Supplementary Figure 3 Change in the number of nonanalgesic prescription drugs over the course of the last 12 months of life, by living arrangement. Standardized for both sex and age (reference: total population). ATC = Anatomical Therapeutic Chemical classification system. The American Journal of Medicine 2017 130, 927-936.e9DOI: (10.1016/j.amjmed.2017.02.028) Copyright © 2017 The Authors Terms and Conditions

Supplementary Figure 4 Polypharmacy (≥10 Drugs) over the course of the last 12 months of life of older people in Sweden, by illness trajectory and age at time of death. The American Journal of Medicine 2017 130, 927-936.e9DOI: (10.1016/j.amjmed.2017.02.028) Copyright © 2017 The Authors Terms and Conditions