Volume 57, Issue 6, Pages (June 2000)

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Volume 57, Issue 6, Pages 2511-2518 (June 2000) Renal blood flow measurement by positron emission tomography using 15O-labeled water Laurent Juillard, Marc F. Janier, Denis Fouque, Martine Lionnet, Didier Le Bars, Luc Cinotti, Paul Barthez, Claude Gharib, Maurice Laville Kidney International Volume 57, Issue 6, Pages 2511-2518 (June 2000) DOI: 10.1046/j.1523-1755.2000.00110.x Copyright © 2000 International Society of Nephrology Terms and Conditions

Figure 1 Renal positron emission tomography (PET) static images using H215O in pigs. Each image represents a transverse slice (0.97 cm thick) where the kidneys and the aorta (arrow on central image) are displayed. (Orientation: Ant = up, Right = left. The upper left image represents the subdiaphragm slice, and the lower right image represents the inferior slice). Reproduction of this figure in color was made possible by SA Ezus-Lyon 1, Villeurbanne, France. Kidney International 2000 57, 2511-2518DOI: (10.1046/j.1523-1755.2000.00110.x) Copyright © 2000 International Society of Nephrology Terms and Conditions

Figure 2 Examples of aortic (•, dashed line) and tissue (solid lines) PET time-activity curves from one pig. Input function (aortic PET time-activity curve) represents the evolution in time of the mean of activity (nCi/mL) measured in the aortic region of interest (ROI). Tissue function (kidney PET time-activity curves) represents the evolution in time of the mean of activity (nCi/mL) measured in the kidney ROI, during baseline (BL; ♦), dopamine infusion (▴), and angiotensin II (Ang II) infusion (▪). Kidney International 2000 57, 2511-2518DOI: (10.1046/j.1523-1755.2000.00110.x) Copyright © 2000 International Society of Nephrology Terms and Conditions

Figure 3 Correlation between RBF (mL · min · 100 g-1) measured by PET using H215O and RBF (mL · min · 100 g-1) measured by ratioactive microspheres (MS) during BL (♦), dopamine infusion (▴), and Ang II infusion (▪; y = 0.79.x + 42, r = 0.93, P < 0.001, N = 18). Kidney International 2000 57, 2511-2518DOI: (10.1046/j.1523-1755.2000.00110.x) Copyright © 2000 International Society of Nephrology Terms and Conditions

Figure 4 Bland and Altman representation of the agreement between RBF (mL · min · 100 g-1) measured with PET using H215O and with MS during BL (♦), dopamine infusion (▴), and Ang II infusion (▪). The mean difference is -17 mL · min · 100 g-1 (mean, dashed line) ± 90 mL · min · 100 g-1 (mean ± 2 SD, dotted line). Kidney International 2000 57, 2511-2518DOI: (10.1046/j.1523-1755.2000.00110.x) Copyright © 2000 International Society of Nephrology Terms and Conditions