Apoptosis in ischemic renal injury: Roles of GTP depletion and p53

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Apoptosis in ischemic renal injury: Roles of GTP depletion and p53 Pierre C. Dagher  Kidney International  Volume 66, Issue 2, Pages 506-509 (August 2004) DOI: 10.1111/j.1523-1755.2004.761_7.x Copyright © 2004 International Society of Nephrology Terms and Conditions

Figure 1 Guanosine triphosphate (GTP) depletion and p53 in ischemia-induced apoptosis. This model proposes that GTP depletion and the activation of p53 are sequential steps underlying the apoptotic phenotype seen after renal ischemia. Guanosine and pifithrin-alpha restore GTP and inhibit p53, respectively, thus preventing apoptosis. Kidney International 2004 66, 506-509DOI: (10.1111/j.1523-1755.2004.761_7.x) Copyright © 2004 International Society of Nephrology Terms and Conditions

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