Volume 78, Issue 5, Pages (September 2010)

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Volume 78, Issue 5, Pages 431-432 (September 2010) Susceptible mice: identifying a diabetic nephropathy disease locus using a murine model Frank C. Brosius Kidney International Volume 78, Issue 5, Pages 431-432 (September 2010) DOI: 10.1038/ki.2010.199 Copyright © 2010 International Society of Nephrology Terms and Conditions

Figure 1 Resistant C57BL/6 (B6) mice were backcrossed with nephropathic FVB/N (FVB) mice to produce diabetic progeny (diabetic F1), which were analyzed for histopathologic features of nephropathy and genotyped for over 100 single-nucleotide polymorphisms. A single locus on chromosome 8 showed a major linkage to the combined nephropathy histology score, suggesting a major contribution of this single gene to the development of nephropathy in FVB diabetic mice. Kidney International 2010 78, 431-432DOI: (10.1038/ki.2010.199) Copyright © 2010 International Society of Nephrology Terms and Conditions