Isolated hevein-like domains, but not 31-kd endochitinases, are responsible for IgE- mediated in vitro and in vivo reactions in latex-fruit syndrome Piia.

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Presentation transcript:

Isolated hevein-like domains, but not 31-kd endochitinases, are responsible for IgE- mediated in vitro and in vivo reactions in latex-fruit syndrome Piia Karisola, MSc, Annika Kotovuori, MSc, Sanna Poikonen, MD, Einari Niskanen, MSc, Nisse Kalkkinen, PhD, Kristiina Turjanmaa, MD, PhD, Timo Palosuo, MD, PhD, Timo Reunala, MD, PhD, Harri Alenius, PhD, Markku S. Kulomaa, PhD Journal of Allergy and Clinical Immunology Volume 115, Issue 3, Pages 598-605 (March 2005) DOI: 10.1016/j.jaci.2004.09.015 Copyright © 2005 American Academy of Allergy, Asthma and Immunology Terms and Conditions

Fig 1 Three or 2 different trend groups were identified with the sera from 5 patients with NRL allergy (P1-P5) in ELISA inhibitions against immobilized prohevein (A1-A3) and immobilized 31-kd endochitinases from banana (B1-B3) and avocado (C1-C3). Journal of Allergy and Clinical Immunology 2005 115, 598-605DOI: (10.1016/j.jaci.2004.09.015) Copyright © 2005 American Academy of Allergy, Asthma and Immunology Terms and Conditions

Fig 2 Average inhibitions of HLDs from WGA (WGAI-WGAIV) and 18-kd WGA against solid-phase hevein are presented, with 17 patients with NRL allergy showing immune responses to hevein. Journal of Allergy and Clinical Immunology 2005 115, 598-605DOI: (10.1016/j.jaci.2004.09.015) Copyright © 2005 American Academy of Allergy, Asthma and Immunology Terms and Conditions

Fig 3 Sequence alignment of HLDs from latex (HEV), avocado (AVO), banana (BAN), and WGA (WGAI-WGAIV) shows identical residues in black and homologous residues in gray. Journal of Allergy and Clinical Immunology 2005 115, 598-605DOI: (10.1016/j.jaci.2004.09.015) Copyright © 2005 American Academy of Allergy, Asthma and Immunology Terms and Conditions

Fig 4 Ribbons present native hevein (red) and modeled HLDs from avocado (green) and banana (yellow; A). On the surface picture of hevein (B) and HLDs from avocado (C) and banana (D), red amino acid residues are identical to the critical residues on the hevein epitope, whereas green residues are substituted in HLDs. Journal of Allergy and Clinical Immunology 2005 115, 598-605DOI: (10.1016/j.jaci.2004.09.015) Copyright © 2005 American Academy of Allergy, Asthma and Immunology Terms and Conditions

Fig 5 C-α traces of native hevein (green) and 4 WGA domains (red) are superimposed (A). The Arg5 of hevein and corresponding amino acid residues in WGA are shown in the stick model. On the surface of WGA (B), red amino acid residues are identical to the critical residues on the hevein epitope, whereas green residues are substituted in WGA. Journal of Allergy and Clinical Immunology 2005 115, 598-605DOI: (10.1016/j.jaci.2004.09.015) Copyright © 2005 American Academy of Allergy, Asthma and Immunology Terms and Conditions