The S130K fibroblast growth factor–1 mutant induces heparin-independent proliferation and is resistant to thrombin degradation in fibrin glue Paula K.

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Presentation transcript:

The S130K fibroblast growth factor–1 mutant induces heparin-independent proliferation and is resistant to thrombin degradation in fibrin glue Paula K. Shireman, MD, Lian Xue, MD, PhD, Ewa Maddox, Wilson H. Burgess, PhD, Howard P. Greisler, MD Journal of Vascular Surgery Volume 31, Issue 2, Pages 382-390 (February 2000) DOI: 10.1016/S0741-5214(00)90168-X Copyright © 2000 Society for Vascular Surgery and International Society for Cardiovascular Surgery, North American Chapter Terms and Conditions

Fig. 1 Molecular degradation of FGF-1 and S130K by thrombin. FGF-1 and S130K were incubated with thrombin 6 U for the specified times (x-axis) and then analyzed by SDS/PAGE. Molecular markers (y-axis) are shown on the left for both gels. FGF-1 and S130K are 17 kd molecules. Both molecules are susceptible to thrombin degradation, but S130K is relatively more resistant than FGF-1, as demonstrated by the delayed appearance and diminished intensity of low molecular weight fragments, suggesting that the mutation offers some protection from thrombin degradation. Journal of Vascular Surgery 2000 31, 382-390DOI: (10.1016/S0741-5214(00)90168-X) Copyright © 2000 Society for Vascular Surgery and International Society for Cardiovascular Surgery, North American Chapter Terms and Conditions