ILK knockdown increases the survival of PKD mice.

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ILK knockdown increases the survival of PKD mice. ILK knockdown increases the survival of PKD mice. (A) Kaplan–Meier survival curve for Ilk+/+;Pkd1fl/fl;Pkhd1-Cre (Ilk+/+ PKD,n=11), Ilkfl/+;Pkd1fl/fl;Pkhd1-Cre (Ilk+/−PKD, n=13), and Ilkfl/fl;Pkd1fl/fl;Pkhd1-Cre (Ilk−/− PKD, n=8) mice. The dotted line represents the time point at which 50% of the mice had died. ILK knockdown in CD cells extended the survival of PKD mice. (B) Heterozygous loss of ILK significantly increased mean survival age from 33±2 for the Ilk+/+ PKD mice to 42±2 days for the Ilk+/− PKD mice, *P<0.05. Complete loss of ILK (Ilk−/− PKD) appeared to extend survival; however, the difference did not reach statistical significance. Archana Raman et al. JASN 2017;28:2708-2719 ©2017 by American Society of Nephrology